Publications of the Synthetic Biology Group

2003


Adams, L. A., Aggarwal, V. K., Bonnert, R. V., Bressel, B., Cox, R. J., Shepherd, J., De Vicente, J., Walter, M., Whittingham, W. G., & Winn, C. L. (2003). Diastereoselective Synthesis of Cyclopropane Amino Acids Using Diazo Compounds Generated in Situ. Journal of Organic Chemistry, 68(24), 9433-9440. https://doi.org/10.1021/jo035060c
Cox, R. J., De Andrés-Gómez, A., & Godfrey, C. R. A. (2003). Rapid and flexible synthesis of 1-deoxy-D-xylulose-5-phosphate, the substrate for 1-deoxy-D-xylulose-5-phosphate reductoisomerase. Organic and Biomolecular Chemistry, 1(18), 3173-3177. https://doi.org/10.1039/b307314a
Reed, M. A. C., Schweizer, M., Szafranska, A. E., Arthur, C., Nicholson, T. P., Cox, R. J., Crosby, J., Crump, M. P., & Simpson, T. J. (2003). The type I rat fatty acid synthase ACP shows structural homology and analogous biochemical properties to type II ACPs. Organic and Biomolecular Chemistry, 1(3), 463-471. https://doi.org/10.1039/b208941f
Nicholson, T. P., Winfield, C., Westcott, J., Crosby, J., Simpson, T. J., & Cox, R. J. (2003). First in vitro directed biosynthesis of new compounds by a minimal type II polyketide synthase: Evidence for the mechanism of chain length determination. Chemical communications, 3(6), 686-687. https://doi.org/10.1039/b300847a

2002


Cox, R. J. (2002). Biosynthesis. Annual Reports on the Progress of Chemistry - Section B, 98, 223-251. https://doi.org/10.1039/b111468a
Cox, R. J., Gibson, J. S., Belén, M., & Martín, M. (2002). Aspartyl phosphonates and phosphoramidates: The first synthetic inhibitors of bacterial aspartate-semialdehyde dehydrogenase. CHEMBIOCHEM, 3(9), 874-886. https://doi.org/10.1002/1439-7633(20020902)3:9<874::AID-CBIC874>3.0.CO;2-V
Arthur, C., Cox, R. J., Crosby, J., Rahman, M. M., Simpson, T. J., Soulas, F., Spogli, R., Szafranska, A. E., Westcott, J., & Winfield, C. J. (2002). Synthesis and characterisation of acyl carrier protein bound polyketide analogues. CHEMBIOCHEM, 3(2-3), 253-257. https://doi.org/10.1002/1439-7633(20020301)3:2/3<253::AID-CBIC253>3.0.CO;2-7
Szafranska, A. E., Hitchman, T. S., Cox, R. J., Crosby, J., & Simpson, T. J. (2002). Kinetic and mechanistic analysis of the malonyl CoA:ACP transacylase from Streptomyces coelicolor indicates a single catalytically competent serine nucleophile at the active site. Biochemistry, 41(5), 1421-1427. https://doi.org/10.1021/bi012001p
Adams, L. A., Cox, R. J., Gibson, J. S., Mayo-Martín, M. B., Walter, M., & Whittingham, W. (2002). A new synthesis of phosphoramidates: inhibitors of the key bacterial enzyme aspartate semi-aldehyde dehydrogenase. Chemical communications, 2(18), 2004-2005. https://doi.org/10.1039/b206199f
Cox, R. J., Crosby, J., Daltrop, O., Glod, F., Jarzabek, M. E., Nicholson, T. P., Reed, M., Simpson, T. J., Smith, L. H., Soulas, F., Szafranska, A. E., & Westcott, J. (2002). Streptomyces coelicolor phosphopantetheinyl transferase: A promiscuous activator of polyketide and fatty acid synthase acyl carrier proteins. Journal of the Chemical Society. Perkin Transactions 1, 14, 1644-1649. https://doi.org/10.1039/b204633b