Research GroupsKalesse Group
Research - Vinylogous Mukaiyama aldol reactions (VMAR)

Research - Vinylogous Mukaiyama aldol reactions (VMAR)

© Daniel Lohrberg/LUH
© Timo Hoffmann/LUH
© Daniel Lohrberg/LUH

We have developed diastereoselective as well as enantioselective vinylogous Mukaiyama aldol reactions on different substrates and substitution patterns.

Tris(pentafluorophenyl)borane-hydrate (TPPB•H2O) works best in our hands with excellent Felkin selectivity.

Enantioselective VMARs mostly use different chiral Lewis acids and, basically all possible methyl group patterns can be obtained specifically.