Research GroupsKirschning Group
research - Technology (Flow)

Flow chemistry

Our research programme on flow chemistry started in 1999 and led to a key publication in 2001 and an early key review in 2003. We cover the development of new, enabling technologies, immbolized (bio)catalysts, and multistep flow synthesis under continuous flow conditions. In 2008 we merged flow chemistry with inductive heating, an enabling technology suited to heat steel reactors or fixed-bed reactor materials based on copper or superparamagnetic nanoparticles (SPION). In combination with water as solvent this high temperature flow technology was exploited to carry out multistep syntheses of important drugs such as iloperidone. 

with U. Kunz, J. Harders, G. Dräger et al., Angew. Chem. Int. Ed. 2001, 40, 3995-3998. 

Reviews: Chem. Eur. J. 2003, 9, 5708-5723; Chem. Eur. J. 2006, 12, 5972-5990; Chem. Commun. 2011, 47, 4583 – 459 and Adv. Synth. Catal. 2012, 354, 17–57.

 

 

ENABLING TECHNOLOGY: INDUCTIVE HEATING (IH) AND FLOW

Inductive heating and mesofluidic reactors are a perfect match of two “Enabling Technologies”. Ferromagnetic materials (e.g. steel beads, copper metal) or superparamagnetic nanoparticles heat up in an oscillating electromagnetic field with medium (MF: 15-25 KHz) or high frequency (HF: 780-850 KHz) using appropriate inductors and coils.

Review on inductive heating: with J. Hartwig and L. Kupracz, Chem. Lett. 2012, 41, 562-570.