New developments in DNA encoded chemistry
Prof. Dr. Andreas Brunschweiger, University Würzburg, Institute for Pharmacy and Food Chemistry, reported on new developments in DNA encoded chemistry during our GDCh kolloqium on 04/12/2025. This exciting technology allows parallel testing of large libraries (containing millions of individual molecules) to identify new binders for difficult-to-target proteins. This is effectively enabled by barcoding each compound with a unique DNA tag, which after the screen can be read out using PCR. Prof. Brunschweiger reported on his work to expand the amendable chemistry for library generation, opening up novel chemical space. This featured combining DNA oligomers with different polymers to improve DNA solubility in organic solvents, allowing to apply different chemistries for functionalization.
For more information see:
- Katharina Götte, Silvia Chines, Andreas Brunschweiger: Reaction development for DNA-encoded library technology: From evolution to revolution?, publicised in Tetrahedron Letters [2020]
- Silvia Chines, Christiane Ehrt, Marco Potowski, Felix Biesenkamp, Lars Grützbach, Susanne Brunner, Frederik van den Broek, Shilpa Bali, Katja Ickstadt, Andreas Brunschweiger: Navigating chemical reaction space– application to DNA-encoded chemistry, publicised in Chemical Science [2022]
