Publikationen der Arbeitsgruppe Kirschning

  • 2020 - heute

    261. F. Wesemann, A. Heutling, P. Wienecke, A. Kirschning, First Ring-Expanded Maytasin Lactone Accessed by a New Mutasynthetic Variant, ChemBioChem, 2020, 21, 2927-2930.

    260. V. Harms, A. Kirschning, J. Dickschat, Nature-driven approaches to non-natural terpene analogues, Nat. Prod. Rep., 2020, 37(8), 1080-1097.  

    259. V. Harms, B. Schröder, C. Oberhauser, C. D. Tran, S. Winkler, G. Dräger, A. Kirschning, Methyl-Shifted Farnesyldiphosphate Derivatives Are Substrates for Sesquiterpene Cyclases, Org. Lett. 2020, 22, 11, 4360–4365 .

    258. W. A. M. Elgaher, M. M. Hamed, S. Baumann, J. Herrmann, L. Siebenbürger, J. Krull, K. Cirnski, A. Kirschning, M. Brönstrup, R. Müller, R. W. Hartmann, Cystobactamid 507: Concise Synthesis, Mode of Action, and Optimization toward More Potent Antibiotics, Chem. Eur. J. 2020, 26, 7219-7225.

    257. T. Planke, K. Cirnski, J. Herrmann, R. Müller, A. Kirschning, Synthetic and Biological Studies on New Urea and Triazole Containing Cystobactamid Derivatives, Chem. Eur. J. 2020, 26(19), 4289-4296.

    256. K. Ekramzadeh, C. Brämer, T. Frister, J. Fohrer, A. Kirschning, T. Scheper, S. Beutel, Optimization of factors influencing enzyme activity and product selectivity and the role of proton transfer in the catalytic mechanism of patchoulol synthase, Biotechnol. Prog., 2020, 36, e2935.

    255. T. Kösel, G. Schulz, G. Dräger, A. Kirschning, Photochemical Transformation with Iodine Azide after Release from an Ion-Exchange Resin, Angew. Chem. - Int. Ed. 2020, 59, 12376-12380.

    254. M. Nawasreh, A. Kirschning, H. Duddeck, G. Dräger, D. Fenske, Novel Double Functional Protection of Cephalostatin Analogues Using a Gas-Free Chlorination Method, Heliyon 2020, 6, 1-8.

  • 2015 - 2019

    253. E. Geist, H. Berneaud-Kötz, T. Baikstis, G. Dräger, A. Kirschning, Towards Chromanes by de Novo Construction of the Benzene Ring, Org. Lett. 2019, 21, 8930-8933.

    252. A. Stepanyuk, A. Kirschning, Synthetic Terpenoids in the World of the Fragrances: Iso E Super® is the Showcase, Beilstein J. Org. Chem. 2019, 15, 2590–2602. 

    251.  M. Moeller, M. D. Norris, T. Planke, K. Cirnski, J. Herrmann, R. Müller, A. Kirschning, Scalable Synthesis of Methoxyaspartate and Preparation of the Antibiotic Cystobactamide 861-2 and Highly Potent Derivatives, Org. Lett. 201921, 8369-8372.

    250. D. H. Banda, P. M. Perin,  R. J. P. Brown, D. Todt, W. Solodenko, P. Hoffmeyer, K. K. Sahu, M. Houghton, P. Meuleman, R. Müller, A. Kirschning, T. Pietschman, A Central Hydrophobic E1 Region Controls the pH of Hepatitis C Virus Membrane Fusion and Susceptibility to Fusion Inhibitors, J. Hepatol. 2019, 70, 1082-1092.

    249. T. Planke, M. Moreno, J. Fohrer, F. Gille, A. Kanakis, M. D. Norris, M. Siebke, L. L. Wang, S. Hüttel, R. Müller, A. Kirschning, The Cystobactamids 920-1 and 920-2: Assignment of the Constitution and Relative Configuration by Total Synthesis, Org. Lett. 2019, 21, 1359-1363.

    248. P.J. Li, G. Dräger, A. Kirschning, A General Biomimetic Hetero-Diels-Alder Approach to the core skeletons of Xenovulene A and Sterhirsutins A and B, Org. Lett. 2019, 12, 998-2001.

    247. M.D. Norris, K. Seidel, A. Kirschning, Externally Induced Drug Release Systems with Magnetic Nanoparticle Carriers: An Emerging Field in Nanomedicine, Adv. Therap. 2019, 2, 1800092.

    246. S. Ullah, K. Seidel, S. Türkkan, D.P. Warwas, T. Dubich, M. Rohde, H. Hauser, P Behrens, A. Kirschning, M. Köster, D. Wirth, Macrophage entrapped silica coated superparamagnetic iron oxide particles for controlled drug release in a 3D cancer model, Journal of Controlled Release 2019, 294, 327–336.

    245A. Kirschning, N. Dibbert, G. Dräger, Chemical functionalization of polysaccharides – towards biocompatible hydrogels for biomedical applications,  Chem. Eur. J. 2018, 24, 1231 –1240.

    244. C. Oberhauser, V. Harms, K. Seidel, B. Schröder, K. Ekramzadeh, S. Beutel, S. Winkler, L. Lauterbach,  J. S.Dickschat, A. Kirschning, Exploiting the synthetic potential of sesquiterpene cyclases for generating unnatural terpenoids,  Angew. Chem. Int. Ed. 2018, 57, 11802 –11806.

    243. M. Wolling, A. Kirschning, Synthesis of the aglycon of the antibiotic disciformycin, Chem. Eur. J. 2018, 648-656.

    242. A. Kirschning, N. Dibbert, G. Dräger, Chemical functionalization of polysaccharides – towards biocompatible hydrogels for biomedical applications, Chem. Eur. J. 2018, 24, 1231 –1240.

    241. H. Sommer, M. Braun, B. Schröder, A. Kirschning, 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one (ETFBO), a versatile precursor for trifluoromethyl substituted hetarenes – a short synthesis of Celebrex® (Celecoxib), Synlett 2018, 29, 121-125.

    240. A. Kipke,K.-U. Schöning, M. Yusubov, A. Kirschning, TEMPO-mediated oxidative deformylation of Aldehydes: Applications in the synthesis of Polyketide fragments, Eur. J. Org. Chem. 2017, 6906-6913.

    239. M. S. Yusubov, P. S. Postnikov, R. Y. Yusubova,A. Yoshimura, G. Jürjens, A. Kirschning, V. V. Zhdankine, 2-Iodoxybenzoic Acid Tosylates: the Alternative to Dess–Martin Periodinane Oxidizing Reagents, Adv. Synth. Catal. 2017, 359, 3207-3216.

    238. S. Hüttel, G. Testolin, J. Herrmann,T. Planke, F. Gille, M. Moreno, M. Stadler, M. Brönstrup, A. Kirschning, R. Müller, Discovery and total synthesis of natural cystobactamid derivatives with superior activity against Gram-negative pathogens, Angew. Chem. Int. Ed. 2017, 56, 12760-12764.

    237. L.-L. Wang, D. Candito, G. Dräger, A. Kirschning, Synthetic Studies Probing Elansolid Biosynthesis: A para-Quinone Methide Triggered Intramolecular Diels-Alder Reaction, Eur. J. Org. Chem. 2017, 37, 5582-5591.

    236. K. Seidel, A. Balakrishnan, C. Alexiou , C. Janko, R-M Komoll, L.-L. Wang, A. Kirschning, M Ott, Synthesis of Magnetic-Nanoparticle/Ansamitocin Conjugates- Inductive Heating Leads to Decreased Cell Proliferation In Vitro and Attenuation of Tumour Growth In Vivo, Chem. Eur. J. 2017, 23, 12326-12337.

    235. L.-L. Wang, A. Kirschning, Total synthesis of elansolids B1 and B2, Beilstein J. Org. Chem. 2017, 13, 1280-1287

    234. L.-L. Wang, D. Candito, G.  Dräger, J. Herrmann, R. Müller, A. Kirschning, Harnessing a p-Quinone Methide Intermediate in the Biomimetic Total Synthesis of the Highly Active Antibiotic 20-Deoxy-Elansolid B1, Chem. Eur. J. 2017, 23, 5291-5298.

    233. L.-L. Wang, A. Balakrishnan, N.-C. Bigall, D. Candito, J.F. Miethe, Y. Xie, K. Seidel, M. Ott, A. Kirschning, A bio-chemosynthetic approach to superparamagnetic iron oxide-ansamytocin conjugates for use in magnetic drug targeting (MDT), Chem. Eur. J. 2017, 23, 2265-2270.

    232. R. Sharma, S. Mohammadi-Ostad-Kalayeh, F. Stahl, C. Zeilinger, G. Dräger, A. Kirschning, P. C. Ravikumar, Two new labdane diterpenoids and one new β-lactam from the aerial parts of Roylea cinerea, Phytochem. Lett. 2017, 19, 101-107.

    231. S. Ceylan, H. Ch.-H. Law, A. Kirschning, P. H. Toy, Organocatalytic Alkyne Isomerizations under Flow Conditions Using Heterogeneous Bifunctional Polystyrene Bearing Phosphine and Phenol Groups, Synthesis 2017, 49, 145-150.

    230. N. Dibbert, A. Krause, J.-C. Rios-Camacho, I. Gruh, A. Kirschning, G. Dräger, A Synthetic Toolbox for the In Situ Formation of Functionalized Homo- and Heteropolysaccharide-Based Hydrogel Libraries, Chem. Eur. J. 2016, 52, 18777-18786.

    229. T. J. Pfeffer, F. Sasse, C. F. Schmidt, S. Lakämper, A. Kirschning, T. Scholz, The natural diterpene tonantzitlolone A and its synthetic enantiomer inhibit cell proliferation and kinesin-5 function, Eur. J. Med. Chem. 2016, 112, 164-170.

    228. J. Donner, M. Reck, S. Bergmann, A. Kirschning, R. Müller, I. Wagner-Döbler, The biofilm inhibitor Carolacton inhibits planktonic growth of virulent pneumococci via a conserved target, Scientific Rep. 2016,, 29677.

    227. T. Busch, G. Dräger, E. Kunst, H. Benson, F. Sasse, K. Seims, A. Kirschning, Synthesis and antiproliferative activity of new tonantzitlolone-derived diterpene derivatives, Org. Biomol. Chem. 2016, 14 , 9040-9045.

    226.  J. Hoepfner, M. Kleinsorge, O. Papp, M. Ackermann, S. Alfken, U. Rinas, W. Solodenko, A. Kirschning, M. Sgodda, T. Cantz, Biphasic modulation of Wnt signaling supports efficient foregut endoderm formation from human pluripotent stem cells, Cell Bio. Int.  2016, 40 , 534-548.

    225. P. M. Perin, S. Haid, R. J. P. Brown, J. Doerrbecker, K. Schulze, C. Zeilinger, M. von Schaewen, B. Heller, K. Vercauteren, E. Luxenburger, Y. M. Baktash, F. W. R. Vondran, S. Speerstra, A. Awadh, F. Mukhtarov, L. M. Schang, A. Kirschning, R. Müller, C. A. Guzman, L. Kaderali, G. Randall, P. Meuleman, A. Ploss,  T. Pietschmann, Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1,  Hepatology 201663, 49-62.

    224. F. Gille, A. Kirschning, Studies on the synthesis of peptides containing dehydrovaline and dehydroisoleucine based on copper-mediated enamide formation, Beilstein J. Org. Chem. 2016, 12, 564-570.

    223. J. Hartwig, A. Kirschning, Flow Synthesis in Hot Water: Synthesis of the Atypical Antipsychotic Iloperidone, Chem. Eur. J. 2016, 22, 3044-3052.

    222. T. J. Pfeffer, F. Sasse, C. F. Schmidt, S. Lakämper, A. Kirschning, T. Scholz, The natural diterpene tonantzitlolone A and its synthetic enantiomer inhibit cell proliferation and kinesin-5 function, Eur. J. Med. Chem. 2016, 112, 164-170. 

    221.  A. Kirschning, F. Gille, M. Wolling, Brook Rearrangement as the Key Step in Domino Reactions, Applications of Domino Transformations in Organic Synthesis Vol. 1 (Science of Synthesis), Georg Thieme Verlag Stuttgart•New-York, 2015, 355-44.

    220. I. Bulyszko, G. Dräger, A. Klenge, A. Kirschning, Evaluation of the Synthetic Potential of an AHBA Knockout Mutant of the Rifamycin Producer Amycolatopsis mediterranei, Chem. Eur. J. 2015, 21, 19231-19242.

    219. J. Hartwig, A. Kirschning, Iterative Syntheses—The Gateway to New Automation Protocols, Angew. Chem. Int. Ed. 2015, 64, 10412-10414.

    218. M. Moreno, W. A. M. Elgaher, J. Herrmann, N. Schläger, M. M. Hamed, S. Baumann, R. Müller, R. W. Hartmann, A. Kirschning, Synthesis and Biological Evaluation of Cystobactamid 507: A Bacterial Topoisomerase Inhibitor from Cystobacter sp., Synlett 2015, 26, 1175-1178.

    217. A. Kirschning, T. A. C. Reydon, Is organic chemistry science – and does this question make any sense at all?, Beilstein J. Org. Chem. 2015, 11, 893-896. 

    216. N. Stumpp, P Premnath, T. Schmidt, J. Ammermann, G. Dräger, M. Reck, R. Jansen, M. Stiesch, I. Wagner-Döbler, A. Kirschning, Synthesis of new carolacton derivatives and their activity against biofilms of oral bacteria, Org. Biomol. Chem. 2015, 13, 5765-5774.

    215. G. Jürjens, A. Kirschning, D. A. Candito, Lessons from the Synthetic Chemist Nature, Nat. Prod. Rep. 2015, 32, 723-737.

    214. J. Franke, M. Bock, R. Dehn, J. Fohrer, S. B. Mhaske, A.Migliorini, A. A. Kanakis, R. Jansen, J. Herrmann, R. Möller, A. Kirschning, Total and Semi-Syntheses of Antimicrobial Thuggacin Derivatives, Chem. Eur. J. 2015, 21, 4272-4284. 

    213. J. Hermane, I. Bulyszko, S. Eichner, F. Sasse, W. Collisi, A. Poso, E. Schax, J.-G. Walter, T. Scheper, K. Kock, C. Hermann, P. Aliuos, G. Reuter, C. Zeilinger, A. Kirschning, New, Non-quinone Fluorogeldanamycin Derivatives Strongly Inhibit Hsp90, Chem. Bio. Chem. 2015, 16, 302-311.

  • 2010 - 2014

    212. L. Mancuso, T. Knobloch, J Buchholz, J. Hartwig, L. Möller, K. Seidel, W Collisi, F. Sasse, A. Kirschning  Preparation of Thermocleavable Conjugates Based on Ansamitocin and Superparamagnetic Nanostructured Particles by a Chemobiosynthetic Approach., Chem. Synth. J. 2014, 20, 17541-17551.

    211. S. R. Chaudhuri, J. Hartwig, L. Kupracz, T. Kodanek,  A. Kirschning, Oxidations of Allylic and Benzylic Alcohols under Inductively- Heated Flow Conditions with Gold-Doped Superparamagnetic Nanostructured Particles as Catalyst and Oxygen as Oxidant, Adv. Synth. Catal. 2014, 356, 3530-3538.

    210. G. Jürjens, A. Kirschning, Pushing Flow Chemistry to New Limits: Development of a Flow Process towards Spirangien A., Chem. Cat. Chem 2014, 6, 2798-2800.

    209. J. Hartwig, J. B. Metternich, N. Nikbin, A. Kirschning, S. V. Ley, Continuous flow chemistry: a discovery tool for new chemical reactivity patterns., Org. Biomol. Chem. 2014, 12, 3611-3615.    

    208. G. Jürjens, A. Kirschning, Synthesis of a Cytotoxic Ansamycin Hybrid, Org. Lett. 2014, 16, 3000-3003. 

    207. S. Umayaparvathi, M. Arumugam, S. Meenakshi, G. Dräger, A. Kirschning, T. Balasubramanian, Purification and Characterization of Antioxidant Peptides from Oyster (Saccostrea cucullata) Hydrolysate and the Anticancer Activity of Hydrolysate on Human Colon Cancer Cell Lines, Int. J. Pept. Res. Ther. 2014, 20, 231-243. 

    206. E. Schax, J.-G. Walter, H. Märzhäuser, F. Stahl, T. Scheper, D. A. Agard, S.
    Eichner, A. Kirschning,  C. Zeilinger,Microarray-Based Screening for Human and Bacterial Hsp90 Inhibitors,J.Biotechnol. 2014, 180, 1-9.

    205. E. Weiss, B. Dutta, A. Kirschning, R. Abu-Reziq, BMIm-PF6@SiO2 Microcapsules: Particulated Ionic Liquids as A New Material for the Heterogenization of Catalysts , Adv. Synth. Catal. 2014, 356, 3530-3538.

    204. E. Geist, A. Kirschning, T. Schmidt, sp 3-sp 3 Coupling reactions in the synthesis of natural products and biologically active molecules, Nat. Prod. Rep. 2014, 31, 441-448.

    203. K. Harmrolfs, L. Mancuso, B. Drung, F. Sasse, A. Kirschning, Preparation of new alkyne-modified ansamitocins by mutasynthesis, Beilstein J. Org. Chem. 2014, 10, 535-543.

    202. A. Weber, R. Dehn, N. Schläger, B. Dieter, A. Kirschning, Total Synthesis of the Antibiotic Elansolid B1, Org. Lett. 2014, 16, 568-571; Highlighted in Synfacts 2014.

    201.  E. Schax, J. Neunaber, F. Stahl, J.-G. Walter, T. Scheper, S. Eichner, A. Kirschning, C. Zeilinger, Multiplexed heat shock protein microarray as a screening platform for the selection of novel drug compounds, Biodiscovery 2014, 14, 1-6. 

    200. Y. Su, J. Palacek, A. Kirschning, G. Dräger,Copper Mediated and Copper Free “Click” Decoration of Polysialic Acid for RGD-Modification and Hydrogel Formation, Macromol. Symp. 2013, 334, 82-91.

    199. L. Kupracz, A. Kirschning, Multiple Organolithium Generation in the Continuous Flow Synthesis of Amitriptyline, Adv. Synth. Catal. 2013, 355, 3375-3380.

    198. S. Cludius-Brandt, L. Kupracz, A. Kirschning, [3+2]-Cycloadditions of nitrile ylides after photo-activation of vinyl azides under flow conditions, Beilstein J. Org. Chem. 2013, 9, 1745-1750.

    197. J. Hartwig, S. Ceylan, L. Kupracz , L. Coutable, A. Kirschning, Heating under High-Frequency Inductive Conditions: Application to the Continuous Synthesis of the Neurolepticum Olanzapine (Zyprexa), Angew. Chem. Int. Ed. 2013, 52, 9813-9817; Highlighted in Synfacts 2013.

    196. J. Franke, S. Eichner, C. Zeilinger , A. Kirschning,Targeting heat-shock-protein 90 (Hsp90) by natural products: geldanamycin, a show case in cancer therapy, Nat. Prod. Rep. 2013, 30, 1299-1323.

    195. L. Mancuso, G. Jürjens, J. Hermane, K. Harmrolfs, S. Eichner, J. Fohrer, W. Collisi, F. Sasse, A. Kirschning, Bioreduction of Aryl Azides during Mutasynthesis of New Ansamitocins,Org. Lett. 2013, 15, 4442-4445.

    194. F. Nador, M. A. Volpe, F. Alonso , A. Feldhoff, A. Kirschning, G. Radivoy, Copper nanoparticles supported on silica coated maghemite as versatile, magnetically recoverable and reusable catalyst for alkyne coupling and cycloaddition reactions, Appl. Catal. A 2013, 455, 39-45.

    193. L. Kupracz , A. Kirschning, Two-Step Flow Synthesis of Biarylmethanes by Reductive Arylation of Tosylhydrazones, J. Flow Chem. 2013, 3, 11-16.

    192. M. S. Yusubov, R. Y. Yusubova, V. N. Nemykin, A. V. Maskaev, M. R. Geraskina, A. Kirschning, V. V. Zhdankin, Potassium 4-iodylbenzenesulfonate: preparation, structure, and application as a reagent for oxidative iodination of arenes, Eur. J. Org. Chem. 2012, 30, 5935-5942.

    191. L. Möller, C. Hess, J.Paleček, Yi Su, A. Haverich, A. Kirschning,G. Dräger, Towards a biocompatible artificial lung: Covalent functionalization of poly(4-methylpent-1-ene) (TPX) with cRGD pentapeptide, Beilstein J. Org. Chem. 2013, 9, 270-277.

    190. J. Dahlmann, A. Krause, L. Möller, G. Kensah, M. Möwes, A. Diekmann, U. Martin, A. Kirschning, I. Gruh, G. Dräger, Myocardial tissue engineering based on novel fully defined in situ cross-linkable alginate and hyaluronic acid hydrogels, Biomaterials 2013, 34, 940-951.

    189. W. Solodenko, A. Doppiu, R. Frankfurter, C. Vogt, A. Kirschning, Silica Immobilized Hoveyda Type Pre-Catalysts: Convenient and Reusable Heterogeneous Catalysts for Batch and Flow Olefin Metathesis, Aust. J. Chem. 2013, 66, 183-191.

    188. E. Borré, M. Rouen, I. Laurent, M. Magrez, F. Caijo, C. Crévisy, W. Solodenko, L. Toupet, R. Frankfurter, C. Vogt,A. Kirschning, M. Mauduit, A Fast-Initiating Ionically-tagged Ru-Complex : A Robust Supported Catalyst for Batch and Continuous Flow Olefin Metathesis, Chem. Eur. J. 2012, 18, 16369-16382.

    187. U. Schön, J. Messinger, W. Solodenko, A. Kirschning, Synthetic approaches towards 4- functionalized estrone derviatives, Synthesis 2012, 44, 3822-3828.

    186. N. Schläger, A. Kirschning, Substrate-controlled stereoselectivity in the Yamamoto aldol reaction, Org. Biomol. Chem. 2012, 10, 7721-7729.

    185. J. Barbier, K. Gerth, R. Jansen, A. Kirschning, Total synthesis of noricumazole B establishes D-arabinose as glycan unit, Org. Biomol. Chem. 2012, 10, 8297-8307.

    184. H. Steinmetz, W. Zander, M.A.M. Shushni, R. Jansen, K. Gerth, R. Dehn, G. Dräger, A. Kirschning, R. Müller, Precursor-directed syntheses and biological evaluation of new Elansolid derivatives, ChemBioChem 2012, 13, 1813-1817.

    183. J. Barbier, J. Wegner, S. Benson, J. Gentzsch, T. Pietschmann, A. Kirschning, Total Synthesis of a Noricumazole A Library and Evaluation of HCV Inhibition, Chem. Eur. J. 2012, 18, 9083-9090.

    182. A. Krause, A. Kirschning, G. Dräger, Bioorthogonal Metal-free Click-Ligation of cRGD-Pentapetide to Alginate, Org. Biomol. Chem. 2012, 10, 5547-5553. 

    181. J. Hartwig, L. Kupracz, A. Kirschning, New Synthetic Opportunities in Miniaturized Flow Reactors with Inductive Heating ,Chem. Lett. 2012, 41, 562-570.

    180. T. Knobloch, G. Dräger, W. Collisi, F. Sasse, A. Kirschning, Unprecedented deoxygenation at C-7 of the ansamitocin core during mutasynthetic biotransformations, Beilstein J. Org. Chem. 2012, 8, 861-869.

    179. F. Taft, S. Eichner, T. Knobloch, K. Harmrolfs, J. Hermane, A. Kirschning, Ansamitocin Libraries by Combining Mutasynthesis with Chemical Synthesis; A New Version of Total Synthesis, Synlett 2012, 23, 1416-1426.

    178. A. Kirschning, F. Hahn, Merging Chemical Synthesis and Biosynthesis: A New Chapter in the Total Synthesis of Natural Products and Natural Product Libraries, Angew. Chem. Int. Ed. 2012, 51, 4012-4022. 

    177.  S. Eichner, T. Knobloch, H. G. Floss, J. Fohrer, K. Harmrolfs, J. Hermane, A. Schulz, F. Sasse, P. Spiteller, F. Taft, A. Kirschning, The Interplay between Mutasynthesis and Semisynthesis: Generation and Evaluation of an Ansamitocin Library, Angew. Chem. Int. Ed. 2012, 51, 752-757.

    176. T. Schmidt, A. Kirschning, Total Synthesis of Carolacton a Highly Potent Biofilm Inhibitor, Angew. Chem. Int. Ed. 2012, 51, 1063-1066. Highlighted in Synfacts 2012.

    175. S. Eichner, T. Eichner, H.G. Floss, J. Fohrer, E. Hofer, F. Sasse, C. Zeilinger, A. Kirschning, Broad substrate specificity of the amide synthase in S. hygroscopicus- new 20-membered macrolactones derived from geldanamycin, J. Am. Chem. Soc. 2012, 134, 1673-1679.

    174. J. Wegner, S.V. Ley, A. Kirschning, A.-L. Hansen, J.M. Garcia, I.R. Baxendale,A Total Synthesis of Millingtonine A, Org. Lett. 2012, 14, 696-699.              

    173. J. Wegner, S. Ceylan, A. Kirschning, Flow Chemistry - A Key Enabling Technology for (Multistep) Organic Synthesis,Adv. Synth. Catal. 2012, 354, 17-57. 

    172. J. Barbier, R. Jansen, H. Irschik, S. Benson, K. Gerth, B. Böhlendorf, G. Höfle, H. Reichenbach, J. Wegner, C. Zeilinger, A. Kirschning, R. Müller, Isolation and Total Synthesis of Icumazoles and Noricumazoles — Antifungal Antibiotics and Cation-Channel Blockers from Sorangium cellulosum,Angew. Chem. Int. Ed. 2012, 51, 1256-1260.

    171. F. Taft, K. Harmrolfs, I. Nickeleit, A. Heutling, M. Kiene, N. Malek, F. Sasse, A. Kirschning,Combined Muta- and Semisynthesis: A Powerful Synthetic Hybrid Approach to Access Target Specific Antitumor Agents Based on Ansamitocin P3,Chem. Eur. J. 2012, 18, 880-886.

    170. L. Möller, A. Krause, I. Bartsch, A. Kirschning, F. Witte, G. Dräger, Preparation and In Vivo Imaging of Lucifer Yellow Tagged Hydrogels,Macromol. Symp. 2011, 309-310, 222-228.

    169. L. Kupracz, J. Hartwig, J. Wegner, S. Ceylan, A. Kirschning,Multistep flow synthesis of vinyl azides and their use in the copper-catalyzed Huisgen-type cycloaddition under inductive-heating conditions, Beilstein J. Org. Chem. 2011, 7, 1441-1448.

    168. J. Paleček, R. Zweigert, R. Olmer, U. Martin, A. Kirschning, G. Dräger, A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and their evaluation in human pluripotent stem cells, Org. Biomol. Chem. 2011, 28, 7739-7744.

    167. R. Jansen, K. Gerth, H. Steinmetz, S.Reinecke, W. Kessler, A. Kirschning, R. Müller, Elansolid A3, a Unique p-Quinone Methide Antibiotic from Chitinophaga sancti, Chem. Eur. J. 2011, 17, 7739-7744.

    166. Dr. R. Dehn, Dr. Y. Katsuyama, A. Weber, Dr. K. Gerth, Dr. R. Jansen, H. Steinmetz, Prof. Dr. G. Höfle, Prof. Dr. R. Müller, Prof. Dr. A. Kirschning, Molecular Basis of Elansolid Biosynthesis: Evidence for an Unprecedented Quinone Methide Initiated Intramolecular Diels-Alder Cycloaddition/Macrolactonization, Angew. Chem. Int. Ed. 2011, 50, 3882-3887. 

    165. L. Möller, A. Krause, J. Dahlmann, I. Gruh, A. Kirschning, G. Dräger, Preparation and evaluation of hydrogel-composites from methacrylated hyaluronic acid, alginate, and gelatin for tissue engineering, Int .J. Artif. Organs. 2011, 34, 93-102.

    164. J. Paleček, G. Dräger, A. Kirschning, A Practical Large-Scale Synthesis of Cyclic RGD Pentapeptides Suitable for Further Functionalization through 'Click' Chemistry, Synthesis, 2011, 4, 653-661.

    163. J. Wegner, S. Ceylan, A. Kirschning, Ten key issues in modern flow chemistry, Org. Biomol. Chem. 2012, 10, 7721-7729.

    162. H. Steinmetz, Dr. K. Gerth, Dr. R. Jansen, N. Schläger, Dr. R. Dehn, S. Reinecke, Prof. Dr. A. Kirschning, Prof. Dr. R. Müller, Elansolid A, a Unique Macrolide Antibiotic from Chitinophaga sancti Isolated as Two Stable Atropisomers, Angew. Chem. Int. Ed. 2011, 50, 532-536.

    161. T. Knobloch, K. Harmrolfs, F. Taft, B. Thomaszewski, F. Sasse, A. Kirschning, Mutational Biosynthesis of Ansamitocin Antibiotics: A Diversity-Oriented Approach to Exploit Biosynthetic Flexibility, ChemBioChem. 2011, 12, 540-547.

    160. S. Ceylan, L. Coutable, J. Wegner, A. Kirschning, Inductive Heating with Magnetic Materials inside Flow Reactors, Chem. Eur. J. 2011, 17, 1884-1893.

    159. K. Harmrolfs, M. Brünjes, G. Dräger, H. G. Floss, F. Sasse, F. Taft, A. Kirschning, Cyclization of Synthetic seco-Proansamitocins to Ansamitocin Macrolactams by Actinosynnema pretiosum as Biocatalyst,ChemBioChem. 2010, 11, 2517-2520.

    158. M.S. Yusubov, R.Y. Yusubova, T.V. Funk, K.-W. Chi, A. Kirschning, V.V. Zhdankin, m-Iodosylbenzoic Acid as a Convenient Recyclable Hypervalent Iodine Oxidant for the Synthesis of α-Iodo Ketones by Oxidative Iodination of Ketones, Synthesis 2010, 21, 3681-3685.

    157. Yi Su, C. Kasper, A. Kirschning, G. Dräger, S. Berski, Synthesis of New Polysialic Acid Derivatives, Macromol. Biosci. 2010, 10, 1028-1033

    156. J. Knochen, U. Kunz, T. Turek, S. Ceylan, A. Kirschning, I. Kampen, M. Vielkind, A. Kwade, S. Arndt, S. Scholl, µ-Consortium: Installation of a mobile Plant for Education and Training in Micro Process Engineering, Chemie Ingenieur Technik 2010, 1799-1806.

    155. M. Baumann, I.R. Baxendale, A. Kirschning, S.V. Ley, J. Wegner, Synthesis of Highly Substituted Nitropyrrolidines, Nitropyrrolizines and Nitropyrroles via Multicomponent-Multistep Sequences within a Flow Reactor, Heterocycles 2010, 82, 77.

    154. J. Wegner, S. Ceylan, C. Friese, A. Kirschning, Inductively Heated Oxides Inside Microreactors - Facile Oxidations under Flow Conditions, Eur. J. Org. Chem. 2010, 23, 4372-4375. 

    153. S. Ceylan, T. Klande, C. Vogt, C. Friese, A. Kirschning, Chemical Synthesis with Inductively Heated Copper Flow Reactors, Synlett 2010, 2009-2013.

    152. M. Vogt, S. Ceylan, A. Kirschning, Stereocontrolled palladium-catalysed umpolung allylation of aldehydes with allyl acetates, Tetrahedron 2010, 66, 6450-6456. 

    151. R. Olmer, A. Haase, S. Merkert, W. Cui, J. Paleček, C. Ran, A. Kirschning, T. Scheper, S. Glage, K. Miller, E. C. Curnow, E. S. Hayes, U. Martin, Long term expansion of undifferentiated human iPS and ES cells in suspension culture using a defined medium,Stem Cell Research 2010, 5, 51-64.

    150. R. Jansen, H. Irschik, V. Huch, D. Schummer, H. Steinmetz, M. Bock, T. Schmidt, A. Kirschning, R. Müller, Carolacton - A Macrolide Ketocarbonic Acid that Reduces Biofilm Formation by the Caries- and Endocarditis-Associated Bacterium Streptococcus mutans, Eur. J. Org. Chem. 2010, 1284-1289.

  • 2005 - 2009

    149. S. Ceylan, A. Kirschning: Organic Synthesis with Mini Flow Reactors Using Immobilised Catalysts; in Recoverable and Recyclable Catalysts, Maurizio Benaglia (ed.), John Wiley & Sons. 2009, 379-410.

    148. K. Mennecke, A. Kirschning: Polyionic polymers - heterogeneous media for metal nanoparticles as catalyst in Suzuki-Miyaura and Heck-Mizoroki reactions under flow conditions; Beilstein J. Org. Chem. 2009, 5: 21.

    147. S. Eichner, H. G. Floss, F. Sasse, A. Kirschning: New, Highly Active Nonbenzoquinone Geldanamycin Derivatives by Using Mutasynthesis; ChemBioChem 2009, 10, 1801-1805.

    146. F. Gallier, H. Hussain, A. Martel, A. Kirschning, G. Dujardin: Hetero-Diels-Alder Reactions of Cyclic Ketone Derived Enamide. A New and Efficient Concept for the Asymmetric Robinson Annulation; Org. Lett. 2009, 11, 3060-3063.

    145. A. Kirschning (Editor): Chemistry in flow systems; Beilstein J. Org. Chem. 2009, 5.

    144. H. Wen, K. Yao, Y. Zhang, Z. Zhou, A. Kirschning: Catalytic transfer hydrogenation of aromatic nitro compounds in presence of polymer-supported nano-amorphous Ni-B catalyst; Catal. Commun. 2009, 10, 1207-1211.

    143. F. Taft, M. Brünjes, T. Knobloch, H. G. Floss, A. Kirschning: Timing of the Δ10,1211,13 Double Bond Migration During Ansamitocin Biosynthesis in Actinosynnema pretiosum; J. Am. Chem. Soc. 2009, 131, 3812-3813.

    142. A. Kirschning, S. Luiken, A. Migliorini, M. A. Loreto, M. Vogt: Studies on the 1,2-Brook Rearrangement of Bissilyl Ketones; Synlett 2009, 3, 429-432.

    141. M. Bock, R. Dehn, A. Kirschning: Total Synthesis of Thuggacin B; Angew. Chem. Int. Ed. 2008, 47, 9134-9137.; Highlighted in Synfacts 2009, 5, 475.

    140. S. Ceylan, C. Friese, C. Lammel, K. Mazac, A. Kirschning: Inductive Heating for Organic Synthesis by Using Functionalized Magnetic Nanoparticles Inside Microreactors; Angew. Chem. Int. Ed. 2008, 47, 8950-8953; Highlighted in Synfacts 2009, 2, 219.

    139. A. Kirschning, L. Gulajski, K. Mennecke, A. Meyer, T. Busch, K. Grela: Highly Active Ammonium-Tagged Olefin-Metathesis Catalyst for Simplified Purification; Synlett 2008, 17, 2692-2696.

    138. K. Mennecke, A. Kirschning: Immobilization of NHC-Bearing Palladium Catalysts on Polyvinylpyridine; Applications in Suzuki-Miyaura and Hartwig-Buchwald Reactions under Batch and Continuous-Flow Conditions; Synthesis 2008, 3267-3272.

    137. A. Kirschning, K. Harmrolfs and T. Knobloch: The chemistry and biology of the maytansinoid antitumor agents; C. R. Chim. 2008, 11, 1523-1543.

    136. T. Busch, H. Schuster, A. Kirschning: Determination of the absolute configuration of the diterpene tonantzitlolone B; Tetrahedron Lett. 2008, 49, 5273-5275.

    135. S. Berski, J. van Bergeijk, D. Schwarzer, Y. Stark, C. Kasper, T. Scheper, C. Grothe, R. Gerardy-Schahn, A. Kirschning, G. Dräger: Synthesis and Biological Evaluation of a Polysialic Acid-Based Hydrogel as Enzymatically Degradable Scaffold Material for Tissue Engineering; Biomacromolecules 2008, 9, 2353-2359.

    134. H.-L. Wen, K.-Sh. Yao, J. Wei, Z.-M. Zhou, A. Kirschning: Preparation and characterization of polymer-supported nano-amorphous Ni-B particles; J. Nanoparticle Res. 2008, 499-503.

    133. K. Mennecke, W. Solodenko, A. Kirschning: Carbon-Carbon Cross-Coupling Reactions under Continuous Flow Conditions Using Poly(vinylpyridine) Doped with Palladium; Synthesis 2008, 1589-1599.

    132. B. Oelze, D. Albert, A. Kirschning: Synthetic and structural studies on macrocyclic amino cyclitols - conformational chameleons; Org. Biomol. Chem. 2008, 6, 2412-2425.

    131. U. Schön, J. Messinger, S. Eichner, A. Kirschning: Comparison of monomode and multimode microwave equipment in Suzuki-Miyaura reactions - en route to high throughput parallel synthesis under microwave conditions; Tetrahedron Lett. 2008, 49, 3204-3207.

    130. A. Kirschning, K. Harmrolfs, K. Mennecke, J. Messinger, U. Schön, K. Grela: Homo- and Heterogeneous Ru-based Metathesis Catalysts in Cross-Metathesis of 15-Propenyl Estrone - Towards 17β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors; Tetrahedron Lett. 2008, 49, 3019-3022.

    129. F. Taft, M. Brünjes, H. G. Floss, N. Czempinski, S. Grond, F. Sasse, A. Kirschning: Highly Active Ansamitocin Derivatives: Mutasynthesis Using an AHBA-Blocked Mutant; ChemBioChem 2008, 9, 1057-1060.

    128. K. Mennecke, R. Cecilia, T. N. Glasnov, S. Gruhl, C. Vogt, A. Feldhoff, M. A. Larrubia Vargas, C. O. Kappe, U. Kunz, A. Kirschning: Palladium(0) Nanoparticles on Glass-Polymer Composite Materials as Recyclable Catalysts: A Comparison Study on their Use in Batch and Continuous Flow Processes; Adv. Synth. Catal. 2008, 350, 717-730.

    127. T. Busch, A. Kirschning: Recent advances in the total synthesis of pharmaceutically relevant diterpenes; Nat. Prod. Rep. 2008, 25, 318-341.

    126. S. Hartlieb, A. Günzel, R. Gerardy-Schahn, A. K. Münster-Kühnel, A. Kirschning, G. Dräger: Chemoenzymatic synthesis of CMP-N-acetyl-7-fluoro-7-deoxy-neuraminic acid; Carbohydr. Res. 2008, 343, 2075-2082.

    125. M. S. Yusubov, R. Y. Yusubova, A. Kirschning, J. Y. Park, K.-W. Chi: m-Iodosylbenzoic acid, a tagged hypervalent iodine reagent for the iodo-functionalization of alkenes and alkynes; Tetrahedron Lett. 2008, 49, 1506-1509.

    124. E. Kunst, F. Gallier, G. Dujardin, A. Kirschning: Glycosidations of 2-deoxy glycosyl dithiophosphates using a tagged iodine(III)-promoter for simple purification; Org. Biomol. Chem. 2008, 6, 893-898.

    123. M. Bock, K. Buntin, R. Müller, A. Kirschning: Stereochemical Determination of Thuggacins A-C, Highly Active Antibiotics from the Myxobacterium Sorangium cellulosum; Angew. Chem. Int. Ed. 2008, 47, 2308-2311.

    122. S. Luiken, A. Kirschning: Polymer-Assisted Dithiane Hydrolysis with Minimum Workup; J. Org Chem. 2008, 73, 2018-2020.; Highlighted in Synfacts 2008, 6, 660.

    121. M. S. Yusubov, T. V. Funk, K. W. Chi, E. H. Cha, G. H. Kim, A. Kirschning, V. V. Zhdankin: Preparation and X-ray structures of 3-[Bis(trifluoroacetoxy)iodo]benzoic acid and 3-[hydroxy(tosyloxy)iodo]benzoic acid: new recyclable hypervalent iodine reagents; J. Org. Chem. 2008, 73, 295-297.

    120. B. Hickstein, R. Cecilia, U. Kunz, U. A. Peuker, A. Kirschning: Magnetiseable function particles for the solid phase support synthesis as example of a transfer hydrogenation response; Chem. Ing. Tech. 2007, 79, 2089-2097.

    119. E. Kunst, F. Gallier, G. Dujardin, M. S. Yusubov, A. Kirschning: Tagged Hypervalent Iodine Reagents: A New Purification Concept Based on Ion Exchange through SN2 Substitution; Org. Lett. 2007, 9, 5199-5202.

    118. G. Dräger, C. Kiss, U. Kunz, A. Kirschning: Enzyme-purification and catalytic transformations in a microstructured PASSflow reactor using a new tyrosine-based Ni-NTA linker system attached to a polyvinylpyrrolidinone-based matrix; Org. Biomol. Chem. 2007, 5, 3657-3664.

    117. G. Dräger, F. Jeske, E. Kunst, E. G. Lopez, H. V. Sanchez, F. Tsichritzis, A. Kirschning, J. Jakupovic: Tonantzitlolone and other Diterpenes from Stillingia sanguinolenta; Eur. J. Org. Chem. 2007, 5020-5026.

    116. A. Kirschning, F. Taft and T. Knobloch: Total synthesis approaches to natural product derivatives based on the combination of chemical synthesis and metabolic engineering; Org. Biomol. Chem. 2007, 5, 3245-3259.

    115. S. Bruns, Y. Stark, S. Röker, M. Wieland, G. Dräger, A. Kirschning, F. Stahl, C. Kasper, T. Scheper: Collagen biomaterial doped with colominic acid for cell culture applications with regard to peripheral nerve repair; J. Biotechnol. 2007, 131, 335-345.

    114. A. Kirschning, M. S. Yusubov, R. Y. Yusubova, K.-W. Chi, J. Y. Park: m-Iodosylbenzoic acid - a convenient recyclable reagent for highly efficient aromatic iodinations; Beilstein J. Org. Chem. 2007, 3: 19.

    113. T. Jöge, M. Jesberger, P. Bröker, A. Kirschning: Synthetic access to spacer-linked 3,6-diamino-2,3,6-trideoxy-α-D-glucopyranosides - potential aminoglycoside mimics for the inhibition of the HIV-1 TAR-RNA/Tat-peptide complex; Carbohydr. Res. 2007, 342, 1704-1714.

    112. A. Meyer, A. Kirschning: Total Syntheses of New Proansamitocin Derivates by Ring-Closing Metathesis; Synlett 2007, 8,1264-1268.

    111. A. Meyer, M. Brünjes, F. Taft, T. Frenzel, F. Sasse, A. Kirschning: Chemoenzymatic Approaches toward Dechloroansamitocin P-3; Org. Lett. 2007, 9, 1489-1492.

    110. H. Clavier, K. Grela, A. Kirschning, M. Mauduit, S. P. Nolan: Clean, green and sustainable - new concepts for metathesis; Angew. Chem. Int. Ed. 2007, 46, 6786-6801

    109. M. S. Yusubov, M. P. Gilmkhanova, V. V. Zhdankin, A. Kirschning: m-Iodosylbenzoic Acid as a Convenient Recyclable Reagent for Highly Efficient RuCl3-Catalyzed Oxidation of Alcohols to Carbonyl Compounds; Synlett 2007, 563-566.

    108. W. Solodenko, G. Jas, U. Kunz, A. Kirschning: Continuous Enantioselective Kinetic Resolution of Terminal Epoxides Using Immobilized Chiral Cobalt-Salen Complexes; Synthesis 2007, 583-589.

    107. E. Schaumann, A. Kirschning: Domino synthesis of carbo- and heterocycles involving 1,3 or 1,4 C-O silyl migration; Synlett 2007, 177-190.

    106. M. Vaultier, A. Kirschning, V. Singh: Task-specific Ionic Liquids as New Phases for Supported Organic Synthesis, Ionic Liquids in Synthesis (eds.: P. Wasserscheidt, T. Welton); Wiley-VCH 2007, Vol. 2, 488-527, ISBN-13: 978-3-527-31239-9 .

    105. A. Kirschning, C. Kujat, S. Luiken, E. Schaumann: Small and versatile - Formyl anion and formyl dianion equivalents; Eur. J. Org. Chem 2007, 2387-2400.

    104. D. Kashin, A. Meyer, R. Wittenberg, K.-U. Schöning, S. Kamlage, A. Kirschning: A practical Synthesis of the Ansa Chain of Benzenic Ansamycin Antibiotics: Total Synthesis of Ansatrienol Derivative; Synthesis 2007, 2, 304-319.

    103. K. M. Dawood, W. Solodenko, A. Kirschning: Microwave-accelerated Mizoroki-Heck- and Sonogashira Cross Coupling Reactions in Water Using a Heterogeneous Palladium(II)-Precatalyst; ARKIVOC 2007, 104-124.

    102. A. Michrowska, K. Mennecke, U. Kunz, A. Kirschning, K. Grela: A New Concept for the Noncovalent Binding of a Ruthenium-Based Olefin Metathesis Catalyst to Polymeric Phases: Preparation of a Catalyst on Raschig Rings; J. Am. Chem. Soc. 2006, 128, 13261-13267 .

    101. C. Jasper, A. Adibekian, T. Busch, M. Quitschalle, R. Wittenberg, A. Kirschning: Total Synthesis of Cyclic Diterpene Tonantzitlolone Based on a Highly Stereoselective Substrate-Controlled Aldol Reaction and Ring-Closing Metathesis; Chem. Eur. J. 2006, 12, 8719-8734.

    100. A. Michrowska, L. Gulajski, Z. Kaczmarska, K. Mennecke, A. Kirschning, K. Grela: A green catalyst for green chemistry - Synthesis and application of an olefin metathesis catalyst bearing a quaternary ammonium group; Green Chem. 2006, 8, 685-688.

    99. D. Raghunathan, V. M. Sánchez-Pedregal, J. Junker, C. Schwiegk, M. Kalesse, A. Kirschning, T. Carlomagno: TAR-RNA recognition by a novel cyclic aminoglycoside analogue; Nucleic Acids Res. 2006, 34, 3599-3608.

    98. C. Brochwitz, A. Feldhoff, U. Kunz, M. Vaultier, A. Kirschning: Comparison and Evaluation of Two Immobilisation Techniques for Task Specific Onium Salts (TSOS) in Mizoroki-Heck Cross Coupling Reactions; Lett. Org. Chem. 2006, 3, 442-446.

    97. A. Kirschning, W. Solodenko, K. Mennecke: Combining Enabling Techniques in Organic Synthesis - Continuous Flow Processes with Heterogenized Catalysts; Chem. Eur. J. 2006, 12, 5972-5990.

    96. T. Kubota, M. Brünjes, T. Frenzel, J. Xu, A. Kirschning, H. G. Floss: Determination of the Cryptic Stereochemistry of the First PKS Chain-Extension Step in Ansamitocin Biosynthesis by Actinosynnema pretiosum; ChemBioChem 2006, 7, 1221-1225.

    95. E. Kunst, A. Kirschning: Total Synthesis of the Trisaccharide Unit of the Molecular Chaperone Down-Regulator Versipelostatin; Synthesis 2006, 2397-2403.

    94. W. Solodenko, K. Mennecke, C. Vogt, S. Gruhl, A. Kirschning: Polyvinylpyridine, a versatile solid phase for coordinative immobilisation of palladium precatalysts - Applications in Suzuki-Miyaura reactions; Synthesis 2006, 1873-1881.

    93. W. Solodenko, P. Bröker, J. Messinger, U. Schön, A. Kirschning: Amidination of amines under microwave conditions using recyclable polymer-bound 1H-pyrazole-1-carboxamidine; Synthesis 2006, 461-466.

    92. C. Kujat, M. Bock, A. Kirschning: Synthesis of the C1-C5 and C6-C24 Fragments of the RNA Polymerase Inhibitors Ripostatin A and B; Synlett 2006, 419-422.

    91. T. Frenzel, M. Brünjes, M. Quitschalle, A. Kirschning: Synthesis of the N-Acetylcysteamine Thioester of seco-Proansamitocin; Org. Lett. 2006, 8, 135-138.

    90. K. M. Dawood, A. Kirschning: Combining enabling techniques in organic synthesis - solid-phase-assisted catalysis under microwave conditions using a stable Pd(II)-precatalyst; Tetrahedron 2005, 61, 12121-12130.

    89. K. Mennecke, K. Grela, U. Kunz, A. Kirschning: Immobilisation of the Grubbs III Metathesis Catalyst with Polyvinyl Pyridine (PVP); Synlett 2005, 2948-2952.

    88. W. Solodenko, C. Brochwitz, R. Wartchow, Md. Abul Hashem, K. Dawood, M. Vaultier, A. Kirschning: 2-Pyridine aldoxime, a new ligand for a Pd-precatalyst - Application in solid-phase-assisted Suzuki-Miyaura reaction; Mol. Diversity 2005, 9, 4, 333-339.

    87. U. Kunz, H. Schönfeld, W. Solodenko, G. Jas, A. Kirschning: Manufacturing and Construction of PASSflow Reactors and their Utilization in Suzuki-Miyaura Cross-coupling Reactions; Ind. Eng. Chem. Res. 2005, 44, 8458-8467.

    86. K. Kloth, M. Brünjes, E. Kunst, T. Jöge, F. Gallier, A. Adibekian, A. Kirschning: Practical TEMPO-Mediated Oxidation of Alcohols using Different Polymer-Bound Co-Oxidants; Adv. Synth. Catal. 2005, 347, 1423-1434.

    85. U. Kunz, A. Kirschning, H.-L. Wen, W. Solodenko, R. Cecilia, C.O. Kappe, T. Turek: Monolithic polymer/carrier materials - Versatile composites for fine chemical synthesis; Catalysis Today 2005, 105, 318-324.

    84. L. Elling, C. Rupprath, N. Günther, U. Römer, S. Verseck. P. Weingarten, G. Dräger, A. Kirschning, W. Piepersberg: An Enzyme Module System for the Synthesis of dTDP-activated Deoxysugars from dTMP and Sucrose; ChemBioChem 2005, 6, 1423-1430.

    83. C. Jasper, R. Wittenberg, M. Quitschalle, J. Jakupovic, A. Kirschning: Total Synthesis and Elucidation of the Absolute Configuration of the Diterpene Tonantzitlolone; Org. Lett. 2005, 7, 3, 479-482.

  • 2000 - 2004

    82. J. Jaunzems, B. Oelze, A. Kirschning: Preparation of macrocyclic 15N-labelled oligoaminodeoxy-saccharides as probes for RNA-binding; Org. Biomol. Chem. 2004, 3448-3456.

    81. A. Kirschning, G. Jas, U. Kunz: Chemistry in Flow - New Continuous Flow Reactors in Organic Synthesis, Innovation and Perspectives in Solid Phase Synthesis - Combinatorial Libraries; Mayflower Worldwide Ltd. 2004, 129-138.

    80. W. Solodenko, H. Wen, S. Leue, F. Stuhlmann, G. Sourkouni-Argirusi, G. Jas, H. Schönfeld, U. Kunz, A. Kirschning: Development of a Continous-Flow System for Catalysis with Palladium(0) Particles; Eur. J. Org. Chem. 2004, 3601-3610.

    79. A. Kirschning, G. Jas: Applications of immobilized catalysts in continuous flow processes; Topics in Current Chemistry, Springer 2004.

    78. J. Jaunzems, D. Kashin, A. Schönberger, A. Kirschning: Polymer-Bound Diphenylphosphane Hydrobromide, a Mild Acid for the Activation of Enol Ethers - Applications in Polymer-Assisted Glycosidations; Eur. J. Org. Chem. 2004, 3435-3446.

    77. W. Solodenko, U. Schön, J. Messinger, A. Glinschert, A. Kirschning: Microwave-Assisted Suzuki-Miyaura Reactions with an Insoluble Pyridine-Aldoxime Pd-Catalyst; Synlett 2004, 10, 1699-1702.

    76. M. Brünjes, C. Kujat, H. Monenschein, A. Kirschning: Acylation of Alkyl Halides and Amino Aldehydes with a Phosphane Oxide based d1-Synthon; Eur. J. Org. Chem. 2004, 1149-1160.

    75. A. Kirschning, G.-w. Chen, J. Jaunzems, M. Jesberger, M. Kalesse, M. Lindner: Synthesis of extended spacer-linked neooligodeoxysaccharides by metathesis olefination and evaluation of their RNA-binding properties; Tetrahedron 2004, 60, 3505-3521.

    74. R. Wittenberg, C. Beier, G. Dräger, G. Jas, C. Jasper, H. Monenschein, A. Kirschning: Towards the total synthesis of Tonantzitlolone - preparation of key fragments and the complete carbon backbone; Tetrahedron Lett. 2004, 45, 4457-4460.

    73. G. Jas, A. Kirschning: Continuous Flow Techniques in Organic Synthesis; Chem. Eur. J. 2003, 9, 5708-5723.

    72. U. Kunz, H. Schönfeld, A. Kirschning, W. Solodenko: Polymer/Carrier composites as materials and reactors for organic synthesis; J. Chromatogr. A 2003, 1006, 241-249.

    71. T. Frenzel, W. Solodenko, A. Kirschning: Solid-Phase Bound Catalysts - Properties and Applications; Polymeric Materials in Organic Synthesis and Catalysis, Wiley-VCH 2003, 201-240.

    70. U. Schön, J. Messinger, N. Merayo, G. Juszkiewicz, A. Kirschning: A Polymer-Bound 1,3-Diketone - A Highly Efficient Scavenger for Hydrazines and Primary Amines; Synlett 2003, 7, 983-986.

    69. A. Kirschning, E. Kunst, M. Ries, L. Rose, A. Schönberger, R. Wartchow: Polymer-bound haloate(I) anions by iodine(III)-mediated oxidation of polymer-bound iodide: Synthetic utility in natural product transformations; Archive for Organic Chemistry 2003, 6, 145-163.

    68. M. Brünjes, G. Sourkouni-Argirusi, A. Kirschning: Polymer-Supported Bisacetoxybromate(I) Anion - An Efficient Co-Oxidant in the TEMPO-Mediated Oxidation of Primary and Secondary Alcohols; Adv. Synth. Catal. 2003, 345, 635-642.

    67. B. Luy, G. Hauser, A. Kirschning, S. J. Glaser: Optimierte NMR-Methode zur Bestimmung der Konfiguration chemisch äquivalenter vicinaler Protonen; Angew. Chem. 2003, 115, 1338-1341.

    66. J. Jaunzems, E. Hofer, M. Jesberger, G. Sourkouni-Argirusi, A. Kirschning: Solid-Phase-Assisted Solution-Phase Synthesis with Minimum Purification - Preparation of 2-Deoxyglycoconjugates from Thioglycosides; Angew. Chem. Int. Ed. 2003, 42, 1166-1170.

    65. J. Jaunzems, G. Sourkouni-Argirusi, M. Jesberger, A. Kirschning: Anomeric activation of thioglycosides and preparation of deoxyglycosides using polymer-bound iodate(I) complexes; Tetrahedron Lett. 2003, 44, 637-639.

    64. A. Kirschning, R. Wittenberg: Merging Solid-Phase and Solution-Phase Synthesis - The "Resin-Capture-Release" Hybrid Technique; Organic Synthesis Highlights V, Wiley-VCH 2003, 265-279.

    63. U. Kunz, A. Kirschning: "A new Microreactor for the Solution-Phase Synthesis of Potential Drugs" M. Matlosz, W. Ehrfeld, J. P. Baselt (Editors); Microreaction Technology Proceedings of the Fifth International Conference on Microreaction Springer-Verlag Berlin- Heidelberg- New York, ISBN 3-540-42498-9, (2002), 424-445

    62. G. Dräger, W. Solodenko, J. Messinger, U. Schön, A. Kirschning: A new reagent and its polymer-supported variant for the amidation of amines; Tetrahedron Lett. 2002, 43, 1401-1403.

    61. H. Monenschein, M. Brünjes, A. Kirschning: Lithiated Dimethoxymethyl Diphenyl Phosphine Oxide, A Versatile Formiate Carbanion Equivalent; Synlett. 2002, 3, 525-527.

    60. W. Solodenko, U. Kunz, G. Jas, A. Kirschning: Polymer-Assisted Horner-Emmons Olefination using PASSflow Reactors: Pure products Without Purification; Bioorg. Med. Chem. Lett. 2002,12, 1833-1835.

    59. G.-w. Chen, A. Kirschning: First Preparation of Spacer-Linked Cyclic Neooligoaminodeoxysaccharides; Chem. Eur. J. 2002, 8, No. 12, 2717-2729.

    58. A. Kirschning, R. Wittenberg, H. Monenschein: Functionalized polymers - Emerging Versatile Tools for Solution-Phase Chemistry and Automated Parallel Synthesis; Angew. Chem. 2001, 113, 670-701; Angew. Chem. Int. Ed. 2001, 40, 650-679.

    57. A. Kirschning, C. Altwicker, G. Dräger, J. Harders, N. Hoffmann, U. Hoffmann, H. Schönfeld, W. Solodenko, U. Kunz: PASSflow Syntheses Using Functionalized Monolithic Polymer/Glass Composites in Flow-Through Microreactors; Angew. Chem. Int. Ed. 2001, 40, 3995-3998.

    56. S. Domann, G. Sourkoni-Argirusu, N. Merayo, A. Schönberger, A. Kirschning: Cohalogenation of Allyl and Vinylsilanes using Polymer-bound Haloate(l)-Reagents; Molecules 2001, 6, 127-132.

    55. A. Kirschning, M. Jesberger and K. U. Schöning: Concepts for the Total Synthesis of Deoxy Sugars; Synthesis 2001, 4, 507-540.

    54. S. Amann, G. Dräger, C. Rupprath, A. Kirschning, L. Elling: (Chemo)enzymatic synthesis of dTDP-activated 2,6-dideoxysugars as building blocks of polyketide antibiotics; Carbohydr. Res. 2001, 335, 23-32.

    53. A. Kirschning, M. Jesberger and A. Schönberger: The First Polymer-Assisted Solution-Phase Synthesis of Deoxyglycosides; Org.Lett. 2001, 3, 23, 3623-3626.

    52. A. Kirschning, G.-w. Chen: Synthesis of spacer-linked tail to tail dimers derived from a conformationally rigid aminodeoxysugar by olefin metathesis; Synthesis 2000, 1133-1137.

    51. A. Kirschning, G.-w. Chen, G. Dräger, I. Schuberth, L. F. Tietze: Synthesis and biological evaluation of new glyco-modified angucyclin-antibiotics; Bioorg. Med. Chem. 2000, 8, 2347-2354.

    50. A. Kirschning: Borohydride exchange resins (BER) - a group of versatile and powerful polymer-supported reductants; J. Prak. Chem. 2000, 342, 508-511.

    49. M. Jesberger, J. Jaunzems, A. Jung, G. Jas, A. Schönberger, A. Kirschning: Soluble versus insoluble polymers as supports for the prepration of new glycosteroids - a practicability study; Synlett 2000, 1289-1293.

    48. D. Hoffmeister, K. Ichinose, S. Domann, B. Faust, A. Trefzer, G. Dräger, A. Kirschning, C. Fischer, E. Künzel, D. W. Bearden, J. Rohr, A. Bechthold: The NDP-sugar co-substrate concentration and the enzyme expression level influence the substrate specificity of glycosyltransferases: cloning and characterization of deoxysugar biosynthetic genes of the urdamycin biosynthetic gene cluster; Chem. Bio. 2000, 7, 821-831.

    47. G. Sourkouni-Argirusi, A. Kirschning: A new polymer-attached reagent for the oxidation of primary and secondary alcohols; Org. Lett. 2000, 2, 3781-3784.

    46. A. Kirschning, R. Wittenberg, H. Monenschein: The "resin-capture-release" hybrid technique: a merger between solid- and solution phase synthesis; Chem. Eur. J. 2000, 6, 4445-4450.

  • 1995 - 1999

    45. S. Lee, A. Kirschning, M. Müller, C. Way, H. G. Floss: Enzymatic Synthesis of [7-14C,-3H]- and [1-13C]-Sedoheptulose-7-phosphate and [1-13C]-ido-heptulose-7-phosphate; J. Mol. Cat. B. Enzym. 1999, 6, 369-377.

    44. A. Kirschning, U. Hary, C. Plumeier, M. Ries, L. Rose: Simple oxidation of 3-O-silylated glycals: application in deblocking 3-O-protected glycals; J. Chem. Soc., Perkin 1, 1999, 519-528.

    43. A. Kirschning, C. Oelkers, M. Ries, A. Schönberger, S.-E. Wohlert, J. Rohr: Studies on Deoxysugars: Biosynthesis and Implications for Enzyme-Mediated Synthesis of Deoxygenated Oligosaccharides; In New Aspects in Bioorganic Chemistry, Hrsg. U. Diederichsen, Th. K. Lindhorst, L. Wessjohann, B. Westermann. Wiley-VCH, 1999.

    42. K.-U. Schöning, R. K. Hayashi, D. R. Powell, A. Kirschning: Synthetic Studies Toward Ansatrienines: Application of the Evans-Tishchenko Reaction to Chiral Enones; Tetrahedron Asymm. 1999, 10, 817-820.

    41. H. Monenschein, G. Dräger, A. Jung, A. Kirschning: Asymmetric Nucleophilic Acylation of Aldehydes via 1,1-Heterodisubstituted Alkenes; Chem. Eur. J. 1999, 5, 2270-2280.

    40. A. Kirschning, G. Chen: Syntheses of Spacer-linked Neodisaccharides Derived from L-Daunosamine; Tetrahedron Lett. 1999, 40, 4665-4668.

    39. A. Kirschning, Md. A. Hashem, H. Monenschein, L. Rose, K.-U. Schöning: Novel Preparation of Haloazide, Equivalents, by Iodine(III)-Promoted Oxidation of Halide Anions; J. Org. Chem. 1999, 64, 6522-6526.

    38. A. Kirschning, H. Monenschein, C. Schmeck: Stable Polymer-Bound Iodine Azide; Angew. Chem. Int. Ed. 1999, 38, 2594-2596.

    37. A. Kirschning, M. Jesberger, H. Monenschein: New polymer-bound electrophilic reagents: applications for the 1,2-functionalization of glycals; Tetrahedron Lett. 1999, 40, 8999-9002.

    36. H. Monenschein, G. Sourkouni, K. M. Schubothe, T. O´Hare, A. Kirschning: Reactions of alkenes, alkynes, and alkoxyallenes with new polymer-supported electrophilic reagents; Org Lett. 1999, 1, 2101-2104.

    35. A. Kirschning, C. Plumeier, L. Rose: Phosphonium Salts of Diacetoxyiodine(I)anions, New Reagents for the Iodoacetoxylation of Alkenes; Chem. Commun. 1998, 11, 33-34.

    34. Md. A. Hashem, A. Jung, M. Ries, A. Kirschning: Iodine(III)-Initiated Bromoacetoxylation of Olefins; Synlett 1998, 195-197.

    33. A. Kirschning: (Diacetoxyiodo)benzene DIB - A Multitalented Oxidant in Organic Synthesis; J. Prakt. Chem. 1998, 340, 184-186.

    32. A. Kirschning, G. Dräger, A. Garming, R. Thiericke, M. Zerlin, C. Maul, M. Noltemeyer: First glycosylation of decarestrictine B and D: A Route to "Hybride" Antibiotics; Chem. Eur. J. 1998, 4, 1324-1331.

    31. A. Kirschning: Hypervalent Iodine and Carbohydrates - A new Liaison; Eur. J. Org. Chem. 1998, 2267-2274.

    30. N. Bräuer, A. Kirschning, E. Schaumann: A Silicon-mediated Synthesis of 3-Deoxy-D-manno-octulosonic Acid (KDO); Eur. J. Org. Chem. 1998, 2729-2732.

    29. A. Kirschning, G. Dräger, A. Jung: A New Enantioselective Formylation of Aldehydes; Angew. Chem.Int. Ed. Engl. 1997, 36, 253-255.

    28. A. Kirschning, M. Ries, S. Domann, W. Martin, W. Albrecht, S. Laufer: Synthesis of the 1-O-Acyl Glucuronide of the Antiinflammatory Drug ML-3000; Bioorg. Med. Chem. Lett. 1997, 7, 903-906.

    27. A. Kirschning, A. Bechthold, J. Rohr: Biochemical Aspects of Deoxysugars and therefrom derived Oligosaccharides; Topics in Current Chemistry, Springer Verlag 1997, Band 188, 1-84.

    26. J. Rohr, S.-E. Wohlert, C. Oelkers, A. Kirschning, M. Ries: Biosynthetic Short Activation of the 2,3,6-Trideoxysugar L-Rhodinose; Chem. Commun. 1997, 10, 973-974.

    25. A. Kirschning, J. Harders: Addition of C-Nucleophiles to Carbohydrate-Derived 2,3-Dihydro-4H-pyran-4-ones: A New Entry to Thromboxane Analogues; Tetrahedron 1997,53, 7867-7876.

    24. J. Harders, A. Garming, A. Jung, V. Kaiser, H. Monenschein, M. Ries, L. Rose, K.-U. Schöning, T. Weber, A. Kirschning: Product Analysis in the Iodine(III)-Promoted Oxidation of Carbohydrate-Derived Cyclic Enol Ethers: A Mechanistic Study; Liebigs Ann. Chem. 1997, 2125-2132.

    23. A. Kirschning, A. Jung, M. Ries, L. Rose: Iod(III)-initiierte Glycosidsynthesen, In Chemie Nachwachsender Rohstoffe; Symposium, Wien, 1997, S. 93-97.

    22. S. Gaisser, A. Trefzer, S. Stockert, A. Kirschning, A. Bechthold: Cloning of an Avilamycin Biosynthetic Gene Cluster from Streptomyces viridochromogenes Tü 57; J. Bacteriol. 1997, 179, 6271-6278.

    21. A. Kirschning, J. Harders: Addition of Silyl- and Stannylanions to Carbohydrate-Derived 2,3-Dihydro-4H-pyran-4-ones: Facile Access to Silyl- and Stannyl Glycosides; Synlett 1996, 772-774.

    20. G. Dräger, A. Kirschning, R. Thiericke, M. Zerlin: Decanolides, 10-Membered Lactones from Natural Origin; Natural Products Reports 1996, 13, 365-375.

    19. C.-G. Kim, A. Kirschning, P. Bergon, P. Zhou, E. Su, B. Sauerbrei, S. Ning, Y. Ahn, M. Breuer, E. Leistner, H. G. Floss: Biosynthesis of 3-Amino-5-hydroxybenzoic Acis, the Precursor of mC7N Units in Ansamycin Antibiotics; J. Am. Chem. Soc. 1996, 118, 7486-7491.

    18. T. Michel, A. Kirschning, C. Beier, N. Bräuer, E. Schaumann, G. Adiwidjaja: Synthesis of Functionalized Carbocycles of Different Ring-Size by a Silicon-Induced Cascade Reaction; Liebigs Ann. Chem. 1996, 1811-1821.

    17. A. Kirschning, G. Dräger: Glycosylierte Decarestrictine - ein Beispiel für hybrid aufgebaute Wirkstoffe; GIT 1996, 1224-1226.

    16. G. Adiwidjaja, H. Flörke, A. Kirschning, E. Schaumann: Electrophile-Induced Cyclizations of Silyl-Substited 4-Alken-1-ols; Liebigs Ann. Chem. 1995, 501.

    15. A. Kirschning: Oxidation of Fully Protected Glycals by Hypervalent Iodine Reagents; J. Org. Chem. 1995, 60, 1228.

    14. A. Kirschning, U. Hary, M. Ries: Syntheses of Specifically Labeled 2,3,6-Trideoxyhexoses; Tetrahedron 1995, 51, 2297.

    13. A. Kirschning, S. Domann, G. Dräger, L. Rose: Iodine(III)-Promoted Azide Transfer to 3-Deoxyglycals; Synlett 1995, 767.

    12. A. Kirschning: 3,4-Di-O-tert.-butyldimethylsilyl-6-O-p-tosyl-D-glucal: A Probe for Mechanistic Studies on Iodine(III)-Promoted Oxidation of Glycals; Liebigs Ann. Chem. 1995, 2053.

    11. G. Adiwidjaja, H. Flörke, A. Kirschning, E. Schaumann: Cyclizations of 5-Silyl-Substituted 4,5-Epoxy-1-alkanols: A Configuration Dependent Mode of Ring Closure; Tetrahedron Lett. 1995, 36, 8771.

  • 1988 - 1994

    10. M.-R. Fischer, A. Kirschning, T. Michel, E. Schaumann: Cyclopentanole durch eine Silicium-induzierte Reaktionskaskade; Angew. Chem. 1994, 106, 220; Angew. Chem. Int. Ed. Engl. 1994, 33, 217.

    9. A. Kirschning, P. Bergon, J. J. Wang, S. Breazeale, H. G. Floss: Synthesis of 4-amino-3,4-dideoxy-D-arabino-heptulosonic-acid-7-phosphate, the Biosynthetic Precursor of C7N-Units in Ansamycin Antibiotics; Carbohydr. Res. 1994, 256, 245.

    8. A. Kirschning, G. Dräger, J. Harders: Regioselective Oxidation of Glycals with Hypervalent Iodine Reagents; Synlett 1993, 289.

    7. A. Kirschning, M. Kreimeyer, H.-P. Blanke: Regioselective Protection of threo-2,3-Dihydroxybutanoic Esters; Tetrahedron: Asymmetry 1993, 4, 2347-2350.

    6. C. G. Kim, A. Kirschning, P. Bergon, Y. Ahn, J. J. Wang, M. Shibuya, H. G. Floss: Formation of 3-Amino-5-hydroxybenzoic Acid, the Precursor of mC(7)N Units in Ansamycin Antibiotics, by a new Variant of the Shikimate Pathway; J. Am. Chem. Soc. 1992, 114, 4941-4943.

    5. A. Kirschning, F. Narjes, E. Schaumann: Synthese von rac-Norartemeseol; Liebigs Ann. Chem. 1991, 933.

    4. E. Schaumann, A. Kirschning, F. Narjes: Synthesis of Vinylcyclopropanes from Epoxides; J. Org. Chem. 1991, 56, 717-723.

    3. E. Schaumann, A. Kirschning: Iodonium-induced Cyclizations of 5-Silylalk-4-enols; J. Chem. Soc. Perkin Trans. I 1990, 1481-1483.

    2. E. Schaumann, A. Kirschning: Regiospecific Synthesis of 1-Silyl substituted 1,4-Dienes; J. Chem. Soc. Perkin Trans. I 1990, 419-421.

    1. E. Schaumann, A. Kirschning: Ring-Opening of Oxiranes by Silyl-substituted Allyl Anions; Tetrahedron Lett. 1988, 29, 4281-4284.

  • weitere Publikationen

    XI. A. Kirschning, S. Eichner, J. Hermane, T. Knobloch: Mutant manufacturers; Drug Discovery from Natural Products 2012, 58-78

    X. T. Knobloch, F. Taft, A. Kirschning: Naturstoffbibliotheken - Mutanten können mehr; Nachr. Chemie 2010, 58, 23-28.

    IX. A. Kirschning: Applications of Hypervalent Iodine In Natural Product Synthesis; Proc. 9th Int. Symp.on Iodine Utilization 2006,143-154.

    VIII. G. Dräger, A. Kirschning (coauthors): Trendbericht Organische Chemie (Kohlenhydrate) 2005; Nachr. Chem. Tech. Lab. 2006, 246-247.

    VII. A. Kirschning (coauthor): Trendbericht Organische Chemie (Kohlenhydrate) 2004; Nachr. Chem. Tech. Lab. 2005, 251-272.

    VI. A. Kirschning (coauthor): Trendbericht Organische Chemie (Kohlenhydrate) 2003; Nachr. Chem. Tech. Lab. 2004, 271-273.

    V. A. Kirschning, G. Jas, U. Kunz: Chemistry in flow - new continuous flow reactors in organic synthesis; Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries (Ed. R. Epton), Mayflower Worldwide Ltd. 2004, 129-138.

    IV. A. Kirschning, H. Monenschein: Polymer-bound ammonium bisazidoiodate (I); e-EROS 2002

    III. A. Kirschning, H. Monenschein: Polymer-bound ammonium bisacetoxybromate (I); e-EROS 2002

    II. A. Kirschning, H. Monenschein: Polymer-bound ammonium bisacetoxyiodate (I); e-EROS 2002

    I. A. Kirschning*, G. Dräger: Glycosylierte Decarestrictine - ein Beispiel für hybrid aufgebaute Wirkstoffe; GIT 1996, 1224-1226.

  • Videos

    Beilstein TV: Inductive heating inside flow reactors; Kupracz, L.; Hartwig, J.; Wegner, J.; Ceylan, S.; Kirschning, A. Beilstein J. Org. Chem. 2011, 7, 1441–1448. doi:10.3762/bjoc.7.168

    Beilstein TV: Mutasynthetic biotransformations; Knobloch, T.; Dräger, G.; Collisi, W.; Sasse, F.; Kirschning, A. Beilstein J. Org. Chem. 2012, 8, 861–869. doi:10.3762/bjoc.8.96

    Beilstein TV: Surface functionalization towards biocompatible medical devices; Möller, L.; Hess, C.; Paleček, J.; Su, Y.; Haverich, A.; Kirschning, A.; Dräger, G. Beilstein J. Org. Chem. 2013, 9, 270–277. doi:10.3762/bjoc.9.33