ArbeitsgruppenAG Cox

Publikationen der Arbeitsgruppe Cox


  • C. Greco, K. de Mattos-Shipley, A. M. Bailey, N. P. Mulholland, J. L. Vincent, C. L. Willis, R. J. Cox and T. J. Simpson (2019) Structure revision of cryptosporioptides and determination of the genetic basis for dimeric xanthone biosynthesis in fungiChem. Sci. 2019 in press
  • Lebe K. E. and Cox R. J. (2019) Oxidative Steps During the Biosynthesis of Squalestatin S1Chem. Sci. 2019 10, 1227
    DOI: 10.1039/c8sc02615g
  • Szwalbe, A. J.; Williams, K.; Song, Z.; de Mattos-Shipley, K.; Vincent, J. L.; Bailey, A. M.; Willis, C. L.; Cox, R. J.; Simpson, T. J. (2019) Characterisation of the biosynthetic pathway to agnestins A and B reveals the reductive route to chrysophanol in fungi.Chemical Science 2019, 10(1), 233-238
    DOI: 10.1039/c8sc03778g
  • de Mattos-Shipley, K. M. J.; Greco, C.; Heard, D. M.; Hough, G.; Mulholland, N. P.; Vincent, J. L.; Micklefield, J.; Simpson, T. J.; Willis, C. L.; Cox, R. J.; et al. (2018) The cycloaspeptides: Uncovering a new model for methylated nonribosomal peptide biosynthesis.Chemical Science 2018, 9(17), 4109-4117
    DOI: 10.1039/c8sc00717a
  • Griffiths S., Cox R. J., Overdijk E., Mesarich C., Saccomanno B., Lazarus C. M., de Wit P., and Collemare J. (2018) Assignment of a dubious gene cluster to melanin biosynthesis in the tomato fungal pathogen Cladosporium fulvum.PLoS ONE 2018 13(12):e0209600
  • He Y., Wang B., Chen W., Cox R. J., He J. and Chen F. (2018) Recent advances in reconstruction microbial seconday metabolites biosynthesis in Aspergillus spp.Biotechnol. 36 (3), 2018 739-783
    DOI: 10.1016/j.biotechadv.2018.02.001
  • He, Y.; Wang, B.; Chen, W.; Cox, R. J.; He, J.; Chen, F. (2018) Recent advances in reconstructing microbial secondary metabolites biosynthesis in Aspergillus spp.Biotechnology Advances 2018, 36(3,SI), 739-783
    DOI: 10.1016/j.biotechadv.2018.02.001
  • Iqbal Z., Han L.-C., Soares-Sello A., Nofiani R., Thormann G., Zeeck A., Willis C. L., R. J. Cox R. J. and Simpson T. J. (2018) Investigations into the biosynthesis of the antifungal strobilurins: biosynthetic inter-relationships and novel halogenated strobilurins from precursor-directed biosynthesisOrg. Biomol. Chem. 2018, 16, 5524-5532
    DOI: 10.1039/C8OB00608C
  • Kuhnert, E.; Li Y.; Lan, N.; Yue, Q.; Chen, L.; Cox, R. J.; An, Z.; Yokoyama, K.; Bills, G. F. (2018) Enfumafungin synthase represents a novel lineage of fungal triterpene cyclases.Environmental Microbiology 2018, 20(9,SI), 3325-3342
    DOI: 10.1111/1462-2920.14333
  • Mattos-Shipley K., Lebe K. E., Han L.-C., Iqbal Z., Bailey A., Willis C., Simpson T. and Cox R. J. (2018) Strobilurin Biosynthesis in Basidiomycete FungiNature Commun. 9, 2018 3940
    DOI: 10.1038/s41467-018-06202-4
  • Nofiani, R.; de Mattos-Shipley, K.; Lebe, K. E.; Han, L.-C.; Iqbal, Z.; Bailey, A. M.; Willis, C. L.; Simpson, T. J.; Cox, R. J. (2018) Strobilurin biosynthesis in Basidiomycete fungi.Nature Communications 2018, 9
    DOI: 10.1038/s41467-018-06202-4
  • Schor, R.; Cox, R. J. (2018) Classic fungal natural products in the genomic age: the molecular legacy of Harold Raistrick.Nat. Prod. Rep. 2018, 35(3), 230-256
    DOI: 10.1039/c8np00021b
  • Schor, R.; Schotte, C.; Wibberd, D.; Kalinowski, J.; Cox, R. J. (2018) Three previously unrecognised classes of biosynthetic enzymes revealed during the production of xenovulene A.Nature Communications 2018, 9
    DOI: 10.1038/s41467-018-04364-9
  • Wasil Z., Kuhnert E., Simpson T. J. and Cox R. J. (2018) Oryzines A & B, Maleidride Congeners from Aspergillus oryzae and Their Putative BiosynthesisJ. fungi 2018 4, 96
    DOI: 10.3390/jof4030096
  • Zulqarnain, Iqbal Z., Cox R. J., Anwar J., Ahmad N., Khan K. and Iqbal M. (2018) Antifungal activity of compounds isolated from Aspergillus niger and their molecular docking studies with tomatinaseNatural Product Research 2018 in press
  • D. M. Roberts, C. Bartel, A. Scott, D. Ivison, T. J. Simpson, R. J. Cox (2017) Substrate selectivity of an isolated enoyl reductase catalytic domain from an iterative highly reducing fungal polyketide synthase reveals key components of programmingChemical Science 2017
    DOI: 10.1039/C6SC03496A
  • Essoung, F. R. E.; Mba'ning, B. M.; Mohamed, S. A.; Lwande, W.; Ngouela, S. A.; Tsamo, E.; Chhabra, S. C.; Hassanali, A.; Cox, R. J. (2017) Welwitschianalol A and B, two cyclohexene derivatives and other insecticidal constituents of Caesalpinia welwitschiana (Oliv.) Brenan.Phytochemistry Letters 2017, 22, 81-86
    DOI: 10.1016/j.phytol.2017.09.010
  • Feng J., Zhang P., Li K., Qiao X., Zhang Y., Li S-M., Cox R. J., Ye M., Yin W.-B. (2017) Discovery of a Novel Phenolic Glycosyltransferase from Mucor hiemalis and Its Catalytic PromiscuityAdvanced Synthesis and Catalysis 2017
    DOI: 10.1002/adsc.201601317
  • Feng, J.; Zhang, P.; Cui, Y.; Li, K.; Qiao, X.; Zhang, Y.-T.; Li, S.-M.; Cox, R. J.; Wu, B.; Ye, M.; et al. (2017) Regio- and Stereospecific O-Glycosylation of Phenolic Compounds Catalyzed by a Fungal Glycosyltransferase from Mucor hiemalis.Advanced Synthesis & Catalysis 2017, 359(6), 995-1006
    DOI: 10.1002/adsc.201601317
  • Gao, S.-S.; Wang, L.; Song, Z.; Hothersall, J.; Stevens, E. R.; Connolly, J.; Winn, P. J.; Cox, R. J.; Crump, M. P.; Race, P. R.; et al. (2017) Selected Mutations Reveal New Intermediates in the Biosynthesis of Mupirocin and the Thiomarinol Antibiotics.Angew. Chem. Int. Edit. 2017, 56(14), 3930-3934
    DOI: 10.1002/anie.201611590
  • Liddle, E.; Scott, A.; Han, C.; Ivison, D.; Simpson, T. J.; Willis, C. L.; Cox, R. J. (2017) In vitro kinetic study of the squalestatin tetraketide synthase dehydratase reveals the stereochemical course of a fungal highly reducing polyketide synthase.Chemical Communications 2017, 53(10), 1727-1730
    DOI: 10.1039/c6cc10172k
  • Roberts, D. M.; Bartel, C.; Scott, A.; Ivison, D.; Simpson, T. J.; Cox, R. J. (2017) Substrate selectivity of an isolated enoyl reductase catalytic domain from an iterative highly reducing fungal polyketide synthase reveals key components of programming.Chemical Science 2017, 8(2), 1116-1126
    DOI: 10.1039/c6sc03496a
  • Trenti, F.; Cox, R. J. (2017) Structural Revision and Biosynthesis of the Fungal Phytotoxins Phyllostictines A and B.J. Nat. Prod. 2017, 80(5), 1235-1240
    DOI: 10.1021/acs.jnatprod.7b00183
  • W. Chen, R. Chen, Q. Liu, Y. He, K. He, X. Ding, L. Kang, X. Guo, N. Xie, Y. Zhou, Y. Lu, R. J. Cox, I. Molnar, M. Li, Y. Shao, F. Chen (2017) Orange, red, yellow: biosynthesis of azaphilone pigments in Monascus fungiChemical Science 2017
    DOI: 10.1039/c7sc00475c
  • Williams K., Szwalbe A. J., Dickson C., Desson T. R., Mulholland N. P., Vincent J. L., Clough J. M., Bailey A. M., Butts C. P., Willis C. L., Simpson T. J., Cox R. J. (2017) Genetic and Chemical Characterisation of the Cornexistin Pathway Provides Further Insight into Maleidride BiosynthesisChem. Commun, 2017, in press
    DOI: 10.1039/C7CC03303F
  • Bailey A., Alberti F., Kilaru S., Collins C., de Mattos-Shipley K., Hartley A., Hayes P., Griffin A., Lazarus C., Cox R. J., Willis C., Spence D., Foster G. (2016) Identification and mainpulation of the pleuromutilin gene cluster from Clitopilus passeckerianus for increased rapid antibiotic productionNature Scientific Report 2016
    DOI: 10.1038/srep25202
  • Bonsch B., Belt V., Bartel C., Duensing N., Konziol M., Lazarus C. M., Bailey A. M., Simpson T. J., Cox R. J. (2016) Identification of Genes Encoding Squalestatin S1 Biosynthesis and in vitro Production of New Squalestatin AnaloguesChemical communications 2016,
    DOI: 10.1039/C6CC02130A
  • Griffiths S., Mesarich C. H., Saccomanno B., Vaisberg A., de Wit P. J. G. M., Cox R. J., Collemare J. (2016) Elucidation of cladofulvin biosynthesis reveals a cytochrome P450 monooxygenase required for anthraquinone dimerizationPNAS USA 2016
    DOI: 10.1073/pnas.1603528113
  • Jones C. R., Greenhalgh M. D., Bame J. R., Simpson T. J., Cox R. J., Marshall J. W., Butts C. P. (2016) Subtle Temperature-Induced Changes in Small Molecule Conformer Dynamics - Observed and Quantified by NOE SpectroscopyChem. Commun. 2016,
    DOI: 10.1039/C5CC10509A
  • K. Williams, A.J. Szwalbe, N.P. Mulholland, J.L. Vincent, A.M. Bailey, C.L. Willis, T.J. Simpson, R.J Cox (2016) Heterologous Production of Fungal Maleidrides Reveals the Cryptic Cyclisation Involved in their BiosynthesisAngew.Chemie 2016
    DOI: 10.1002/anie.201511882
  • A. Abooda, A. Al-Fahad, A. El-Dein, M. Hosny, A. M. Hashem, A. M. A. Fattah, P. R. Race, T. J. Simpson and R. J. Cox (2015) Kinetic characterisation of the FAD dependent monooxygenase TropB and investigation of its biotransformation potentialRSC Advances 2015,
    DOI: 10.1039/C5RA06693J
  • M. H. Medema, R. Kottmann, P. Yilmaz, R.J. Cox, (2015) Minimum Information about a Biosynthetic Gene clusterNature Chemical Biology 2015
    DOI: 10.1038/nchembio.1890
  • Szwalbe A. J., Williams K., O'Flynn D. E., Bailey A. M., Mulholland N. P., Vincent J. L., Willis C. L., Cox R. J., Simpson T. J. (2015) Novel nonadride, heptadride and maleic acid metabolites from the byssochlamic acid producer Byssochlamys fulva IMI 40021 - an insight into the biosynthesis of maleidridesChem. Commun 2015
    DOI: 10.1039/C5CC06988B
  • Y. He, R.J. Cox (2015) The Molecular Steps of Citrinin Biosynthesis in FungiChemical Science 2015
    DOI: 10.1039/C5SC04027B
  • Z. Song, W. Bakeer, J. W. Marshall, A. A. Yakasai, R. M. Khalid, J. Collemare, E. Skellam, D. Tharreau, M.-H. Lebrun, C. M. Lazarus, A. M. Bailey, T. J. Simpson and R. J. Cox (2015) Heterologous Expression of the Avirulence gene ACE1 from the fungal rice pathogen Magnoporthe oryzaeChemical Science 2015
    DOI: 10.1039/C4SC03707C
  • A. Al-Fahad, A. Abood, K. M. Fisch, A. Osipow, J. Davison, M. Avramovic, C. P. Butts, J. Piel, T. J. Simpson, R. J. Cox (2014) Oxidative Dearomatisation: The Key Step of Sorbicillinoid BiosynthesisChem. Sci. 2014, 5, 523-527.
    DOI: 10.1039/C3SC52911H
  • A. Al-Fahad, A. Abood, T. J. Simpson, R. J. Cox (2014) The Biosynthesis and Catabolism of the Maleic Anhydride Moiety of Stipitatonic AcidAngew. Chem. Int. Ed. 2014, 53 (29), 7519-7523
    DOI: 10.1002/anie.201403450
  • A. C. Murphy, S. Gao, L. C. Han, S. Carobene, D. Fukuda, Z. Song, J. Hothersall, R. J. Cox, J. Crosby, M. P. Crump, C. M. Thomas, C. L. Willis, T. J. Simpson (2014) Biosynthesis of thiomarinol A and related metabolites of Pseudoalteromonas sp. SANK 73390Chemical Science 2014, 5, 397-402.
    DOI: 10.1039/c3sc52281d
  • A. Latif, S. H. Hussain, M. Ali, M. Arfan, M. Ahmed, R. J. Cox, T. J. Simpson, G. Uddin (2014) A New Antioxidant Triterpenoid from the Stem Wood of Sorbus lanataRec. Nat. Prod. 2014, 8, 19-24.
  • Hussain, SH ; Latif, A ; Cox, RJ ; Simpson, TJ ; Ali, M ; Arfan, M ; Uddin, G (2014) Phytochemicals from the aerial parts of Ligularia thomsonii and their radical scavenging activityPHYTOCHEMISTRY LETTERS, 2014, 7
    DOI: 10.1016/j.phytol.2013.09.002
  • J. Collemare, S. Griffiths, Y. Iida, M. K. Jashni, E. Battaglia, R. J. Cox, P. J. G. M. de Wit (2014) Secondary Metabolism and Biotrophic Lifestyle in the Tomato Pathogen Cladosporium fulvumPLoS ONE 2014, 9(1): e85877.
    DOI: 10.1371/journal.pone.0085877
  • Ökmen B., Collemare J., Griffiths S., van der Burgt A., Cox R. J. and de Wit P. J. G. M. (2014) Functional analysis of the conserved transcriptional regulator CfWor1 in Cladosporium fulvum reveals diverse roles in the virulence of plant pathogenic fungiMOLECULAR MICROBIOLOGY, 2014, 92, Issue 1, 10–27.
    DOI: 10.1111/mmi.12535
  • R. J. Cox (2014) Oxidative Rearrangements during Fungal BiosynthesisNat. Prod. Rep. 2014, 31 (10), 1405-1424
    DOI: 10.1039/C4NP00059E
  • R. J. Cox (2014) β-Chain Extension: A New Mode of Carbon-Carbon Bond Formation and Chain Extension by Polyketide SynthasesChemBioChem 2014, 15, 27-29.
    DOI: 10.1002/cbic.201300660
  • S.-S. Gao, J. Hothersall, J. Wu, A. C. Murphy, Z. Song, E. R. Stephens, C. M. Thomas, M. P. Crump, Russell J Cox, T. J. Simpson, and C. L. Willis (2014) Biosynthesis of Mupirocin by Pseudomonas fluorescens NCIMB 10586 Involves Parallel PathwaysJ. Am. Chem. Soc. 2014, 136, 5501–5507.
    DOI: 10.1021/ja501731p
  • A. Munawar, J. W. Marshall, R. J. Cox, A. M. Bailey* and C. M. Lazarus* (2013) Isolation and Characterisation of a Ferrirhodin Synthetase Gene from the Sugarcane Pathogen Fusarium sacchariChemBioChem 2013, 14(3), 388-394.
    DOI: 10.1002/cbic.201200587
  • A. S. Haines, X. Dong, Z. Song, R. Farmer, C. Williams, J. Hothersall, E. Płoskoń, P. Wattana-Amorn, E. R. Stephens, E. Yamada, R. Gurney, Y. Takebayashi, J. Masschelein, R. J. Cox, R. Lavigne, C. L. Willis, T. J. Simpson, J. Crosby, P. J. Winn, C. M. Thomas and M. P. Crump (2013) A conserved motif flags acyl carrier proteins for β-branching in polyketide synthesisNat. Chem. Biol. 2013, 9, 11, 685–692.
    DOI: 10.1038/nchembio.1342
  • G. Uddin, A. Latif, M. Arfan, M. Ali, S. H. Hussain, T. J. Simpson, R. J. Cox and M. I. Choudhary (2013) Phytochemicals from the stem wood of Sorbus lanata (D. Don.) SchauerPhytochem. Lett. 2013, 6(1), 84-89.
    DOI: 10.1016/j.phytol.2012.10.002
  • K. M. Fisch (2013) Biosynthesis of natural products by microbial iterative hybrid PKS-NRPSReview article, 2013, accepted by RSC Advances.
  • M. V. Gammons, O. Fedorov, D. Ivison, C. Y. Du, T. Clark, C. Hopkins, M. Hagiwara, A. D. Dick, R. Cox, S. J. Harper, J. C. Hancox, S. Knapp and D. O. Bates (2013) Topical Antiangiogenic SRPK1 Inhibitors Reduce Choroidal Neovascularization in Rodent Models of Exudative AMDInvest. Ophthalmol. Vis. Sci. 2013, 54, 9, 6052-6062.
    DOI: 10.1167/iovs.13-12422
  • R. J. Cox, A. Al-Fahad (2013) Chemical mechanisms involved during the biosynthesis of tropolonesCurr. Opin. Chem. Biol., 2013, 17, 532-536. Weitere Informationen
  • R. J. Cox, Z. Wasil, M. Pahirulzaman, C. Butts, T. J. Simpson and C. M. Lazarus (2013) One Pathway, Many Compounds: Heterologous Expression of a Fungal Biosynthetic Pathway Reveals its Intrinsic Potential for DiversityChem. Sci. 2013, 4, 3845.
    DOI: 10.1039/C3SC51785C
  • S. H. Hussain, A. Latif, M. Arfan, M. Ali, T. J. Simpson, R. J. Cox, F. Shaheen, G. Uddin (2013) A New Bezoxepin Derivative from Senecio desfontaineiRec. Nat. Prod. 2013, 7, 4, 325-331.
  • A K Pahirulzaman, K., Williams, K., and Lazarus, C.M. (2012) A Toolkit for Heterologous Expression of Metabolic Pathways in Aspergillus oryzaeMethods in Enzymology, 2012, 517, 241-260.
  • C. G. Girol, K .M. Fisch, T. Heinekamp, S. Günther, W. Hüttel, J. Piel, A. A. Brakhage, M. Müller (2012) Regio- and Stereoselective Oxidative Phenol Coupling in Aspergillus nigerAngew. Chem. Int. Ed., 2012, 51, 9788-9791.
  • J. Davison, A. al Fahad, M. Cai, Z. Song, S. Yehia, C. M. Lazarus, A. M. Bailey, T. J. Simpson and R. J. Cox* (2012) Genetic, Molecular and Biochemical Basis of Fungal Tropolone BiosynthesisProc. Natl. Acad Sci USA 2012, 109(20), 7642-7647.
  • A. C. Murphy, D. Fukuda, Z. Song, J. Hothersall, R. J. Cox, C. L. Willis, C. M. Thomas and T. J. Simpson* (2011) Engineered Thiomarinol Antibiotics Active against MRSA Are Generated by Mutagenesis and Mutasynthesis of Pseudoalteromonas SANK73390Angew. Chem. Int. Ed., 2011, 50, 3271-3274.
    DOI: 10.1002/anie.201007029
  • A. S. Evitt and R. J. Cox* (2011) Synthesis and Evaluation of Conformationally Restricted Inhibitors of Aspartate Semialdehyde DehydrogenaseMol. Biosyst., 2011, 7(5), 1564-1575.
  • D. Fukuda, A. S. Haines, Z. Song, A. Murphy, J. Hothersall, E. Stephens, R. Gurney, R. J. Cox, J. Crosby, C. Willis, T. J. Simpson, C. M. Thomas* (2011) A natural plasmid encoding two antibiotic synthases creates a potent conjugate active against MRSAPLOS1, 2011, 6(3), e18031.
  • J. Hothersall, A. C. Murphy, Z. Iqbal, G. Campbell, E. R. Stephens, J. Wu, H. Cooper, S. Atkinson, P. Williams, J. Crosby, C. L. Willis, R. J. Cox, T. J. Simpson, C. M. Thomas (2011) Manipulation of quorum sensing regulation in Pseudomonas fluorescens NCIMB 10586 to increase mupirocin productionAppl. Microbiol. Biotechnol., 2011, 90(3), 1017-1026.
  • K. M. Fisch, W. Bakeer, A. A. Yakasai, Z. Song, J. Pedrick, Z. Wasil, A. M. Bailey, C. M. Lazarus, T. J. Simpson, and R. J. Cox* (2011) Rational Domain Swaps Decipher Programming in Fungal Highly Reducing Polyketide Synthases and Resurrect an Extinct MetaboliteJ. Am. Chem. Soc., 2011, 133, 16635-16641.
  • M. N. Heneghan, A. A. Yakasai, K. Williams, K. A. Kadir, Z. Wasil, W. Bakeer, K. M. Fisch, A. M. Bailey, T. J. Simpson, R. J. Cox* and C. M. Lazarus (2011) The Programming Role of Trans-Acting Enoyl Reductases During the Biosynthesis of Highly Reduced Fungal PolyketidesChem. Sci, 2011, 2(5), 972-979.
  • R. W. Scott, A. C. Murphy, J. Wu, J. Hothersall, R. J. Cox, T. J. Simpson, C. M. Thomas and C. L. Willis* (2011) Mupirocin F: structure elucidation, synthesis and rearrangementsTetrahedron, 2011, 67, 5098-5106.
  • Yakasai A. A., Davison J., Wasil Z., Halo L., Butts C. P., Lazarus C. M., Bailey A. M., Simpson T. J. and Cox R. J. (2011) Nongenetic Reprogramming of a Fungal Highly Reducing Polyketide SynthaseJ. Am. Chem. Soc., 2011, 133, 10990-10998.
    DOI: 10.1021/ja204200x
  • E. J. Skellam, D. Hurley, J. Davison, C. M. Lazarus, T. J. Simpson and R. J. Cox,* (2010) Mutation of Key Residues in the C-methyltransferase Domain of a Fungal Highly Reducing Polyketide SynthaseMol. Biosyst., 2010, 6, 680-882.
  • J. Wu,* H. B. Zhang, J. L. Xu, R. J. Cox, T. J. Simpson and L. H. Zhang (2010) C-13 Labeling reveals multiple amination reactions in the biosynthesis of a novel polyketide polyamine antibiotic zeamine from Dickeya zeaeChem. Commun., 2010, 46, 333-335.
  • K. M. Fisch, E. Skellam, D. Ivison, R. J. Cox,* A. M. Bailey, C. M. Lazarus and T. J. Simpson (2010) Catalytic Role of the C-Terminal Domains of a Fungal Non-Reducing Polyketide SynthaseChem. Commun., 2010, 46, 5331-5333.
  • M. N. Heneghan, A. A. Yakasai, L. M. Halo, Z. Song, A. M. Bailey, R. J. Cox*, T. J. Simpson and C. M. Lazarus (2010) The First Heterologous Reconstruction of a Complete Functional Fungal Biosynthetic Multi-Gene ClusterChemBioChem, 2010, 11, 1508-1512.
  • P. Wattana-Amorn, C. Williams, E. Ploskon, R. J. Cox, T. J. Simpson, J. Crosby, M. P. Crump (2010) Solution Structure of an Acyl Carrier Protein Domain from a Fungal Type I Polyketide SynthaseBiochemistry, 2010, 49, 2186-2193.
  • Russell J. Cox* and Thomas J. Simpson,* (2010) Fungal Type I Polyketidesin Comprehensive Natural Products II: Volume 1, p 347-383, Elsevier, 2010.
  • A. Abdel-Lateff, K. M. Fisch, A. D. Wright (2009) Trichopyrone: A New Pyrone Derivative from the Marine Sponge-Derived Fungus Trichoderma sp.Zeitschrift für Naturforschung C, 2009, 64, 186-192.
  • K. M. Fisch, A. F. Gillaspy, M. Gipson, J. C. Henrikson, A. R. Hoover, L. Jackson, F. Z. Najar, H. Wägele, R. H. Cichewicz (2009) Chemical induction of silent biosynthetic pathway transcription in Aspergillus nigerJ. Ind. Microbiol. Biotechnol., 2009, 9, 1199-1213.
  • K. M. Fisch, C. Gurgui, N. Heycke, S. van der Sar, S. A. Anderson, V. Webb, S. Taudien, M. Platzer, B. K. Rubio, S. J. Robinson, P. Crews, J. Piel (2009) Structure-based targeting of polyketide biosynthesis genes in highly complex metagenomes of marine spongesNat. Chem. Biol., 2009, 5, 494-501.
  • P. Beltran-Alvarez, C. J. Arthur, R. J. Cox,* J. Crosby, M. P. Crump and T. J. Simpson (2009) Preliminary Kinetic Analysis of Acyl Carrier Protein:Ketoacylsynthase Interactions in the Actinorhodin Minimal Polyketide SynthaseMolcular Biosystems, 2009, 5, 511-518.
  • R. J. Cox,* T. J. Simpson,* (2009) Fungal Type I Polyketide Synthases, Complex Enzymes In Microbial Natural Product Biosynthesis, Part B: Polyketides, Aminocoumarins And CarbohydratesMethods In Enzymology, 2009, 459, 49-78.
  • S. E. Evans, C. Williams, C. J. Arthur, E. Ploskon, P. Wattana-Amorn, R. J. Cox, J. Crosby, C. L. Willis, T. J. Simpson and M. P. Crump,* (2009) Probing the Interactions of Early Polyketide Intermediates with the Actinorhodin ACP from S. coelicolor A3(2)J. Mol. Biol., 2009, 389, 511-528.
  • J. Wu, J. Hothersall, C. Mazzetti, Y. O’Connell, J. A. Shields, A. S. Rahman, R. J. Cox, J. Crosby, T. J. Simpson,* C. M. Thomas and C. L. Willis (2008) In vivo Mutational Analysis of the Mupirocin Gene Cluster Reveals Labile Points in the Biosynthetic Pathway: the 'Leaky Hosepipe' MechanismChemBioChem, 2008, 9, 1500-1508.
  • L. M. Halo, J. W. Marshall, A. A. Yakasai, Z. Song, C. P. Butts, M. P. Crump, M. Heneghan, A. M. Bailey, T. J. Simpson, C. M. Lazarus, and R. J. Cox,* (2008) Authentic Heterologous Expression Of The Tenellin Iterative Polyketide Synthase Non-Ribosomal Peptide Synthetase requires co-expression with an enoyl reductaseChemBioChem, 2008, 9, 585-594.
  • L. M. Halo, M. N. Heneghan, A. A. Yakasai, Z. Song, K. Williams, A. M. Bailey, R. J. Cox,* C. M. Lazarus, and T. J. Simpson (2008) Late stage oxidations during the biosynthesis of the 2-pyridone tenellin in the entomopathogenic fungus Beauveria bassianaJ. Am. Chem. Soc., 2008, 130, 17988-17996.
  • R. J. Cox and T. J. Simpson,* (2008) Polyketide Biosynthesis, FungiWiley Encyclopaedia of Chemical Biology, August 15th, 2008.
    DOI: 10.1002/9780470048672.wecb458
  • A. M. Bailey, R. J. Cox,* K. Harley, C. M. Lazarus, T. J. Simpson* and E. Skellam (2007) Characterisation of 3-methylorcinaldehyde synthase (MOS) in Acremonium strictum: first observation of a reductive release mechanism during polyketide biosynthesisChem. Commun., 2007, 4053-4055.
  • D. O. Rees, N. Bushby, R. J. Cox, J. R. Harding, T. J. Simpson* and C. L. Willis,* (2007) Synthesis of 1,2-13C215N.-L-Homoserine and Incorporation by the PKS-NRPS System of Fusarium moniliforme into the Mycotoxin Fusarin CChemBioChem, 2007, 8, 46-50.
  • I. Eleftherianos, S. Boundy, S. A. Joyce, J. W. Marshall, R. J. Cox, T. J. Simpson, D. J. Clarke, R. H. ffrench-Constant and S. E. Reynolds,* (2007) An antibiotic produced by an insect-pathogenic bacterium inhibits host defences through phenoloxidase inhibitionProc. Natl. Acad. Sci. USA, 2007, 104(7), 2419-2424.
  • J. Hothersall, J. Wu, A. S. Rahman, J. A. Shields, J. Haddock, N. Johnson, S. M Cooper, E. Stephens, R. J. Cox, J. Crosby, C. L. Willis, T. J Simpson and C. M. Thomas* (2007) Mutational analysis reveals that all tailoring region genes are required for production of polyketide antibiotic mupirocin by Pseudomonas fluorescens: Pseudomonic acid B biosynthesis precedes pseudomonic acidJ. Biol. Chem., 2007, 282, 15451-15461.
  • J. Wu, S. M. Cooper, R. J. Cox, J. Crosby, M. P. Crump, J. Hothersall, T. J. Simpson,* C. M. Thomas and C. L. Willis (2007) Mupirocin H, a novel metabolite resulting from mutation of the HMG-CoA synthase analogue, mupH in Pseudomonas fluorescensChem. Commun., 2007, 2040-2042.
  • K. L. Eley, L. M. Halo, Z. Song, H. Powles, R. J. Cox,* A. M. Bailey, C. M. Lazarus and T. J. Simpson (2007) Biosynthesis of the 2-Pyridone Tenellin in the Insect Pathogenic Fungus Beauveria bassianaChemBioChem, 2007, 8, 289-297.
    DOI: 10.1002/cbic.200600398
  • K. M. Fisch, J. Haier (2007) Models for Tumour Cell Adhesion and Invasionbook chapter in “The Cancer Handbook Second Edition”, ed. by Macolm Alison, John Wiley & Sons Limited, 2007, 992-1004.
  • P. Beltran-Alvarez, R. J. Cox,* J. Crosby and T. J. Simpson (2007) Dissecting the Component Reactions Catalysed by the Actinorhodin Minimal Polyketide SynthaseBiochemistry, 2007, 46, 14672-14681.
  • R. J. Cox* (2007) The Biosynthesis of polyketides, tetramic acids and pyridones in fungiACS Symposium Series on Polyketides: Biosynthesis, Biological Activity and Genetic Engineering, 2007, 955, chapter 3, 33-47.
  • R. J. Cox* (2007) Polyketides, Proteins and Genes in Fungi: Programmed Nano-Machines Begin to Reveal Their SecretsOrg. Biomol. Chem., 2007, 5, 2010-2026.
  • R. J. Cox* and A. S. Evitt (2007) Acyl Palladium Species in Synthesis: Single Step Synthesis of α,β-Unsaturated Ketones from Acid ChloridesOrg. Biomol. Chem., 2007, 5, 229-232.
  • R. J. Cox* and U. Wong (2007) The Chemical Mechanism of D-1-deoxyxylulose-5-phosphate reductoisomerase from Escherichia coliAngew. Chem. Int Ed. Engl., 2007, 46, 4926-4929.
  • C. J. Arthur, A. E. Szafranska, J. Long, J. Mills, R. J. Cox, S. C. Findlow, T. J. Simpson, M. P. Crump and J. Crosby* (2006) The malonyl transferase activity of type II polyketide synthase acyl carrier proteinsChem. Biol., 2006, 13, 587-596.
  • Gibson, W., Peacock, L., Ferris, V., Williams, K., and Bailey, M. (2006) Analysis of a cross between green and red fluorescent trypanosomesBiochemical Society Transactions, 2006, 34, 557-559.
  • K. M. Fisch, A. Abdel-Lateff, G. M. König (2006) Antioxidant metabolites from marine derived fungibook chapter in “Biomaterials from Aquatic and Terrestrial Organisms” ed. by Fingerman, M. and Nagabhushanam, R., Science Publishers, New Hampshire, 2006, 361-376.
  • Y. Ma, L. H. Smith, R. J. Cox,* P. Beltran-Alvarez, C. J. Arthur and T. J. Simpson (2006) Catalytic Relationships between Type I and Type II Iterative Polyketide Synthases: The Aspergillus parasiticus Norsolorinic Acid SynthaseChemBioChem, 2006, 7, 1951-1958.
  • A. von Sengbusch, P. Gassmann, K. M. Fisch, A. Enns, G. L. Nicolson, J. Haier (2005) Focal adhesion kinase regulates metastatic adhesion of carcinoma cells within liver sinusoidsAm. J. Pathol., 2005, 166, 585-596.
  • L. Mercklé, A. de Andrés-Gómez, B. Dick, R. J. Cox* and C. R. A. Godfrey (2005) A Fragment-Based Approach to Understanding Inhibition of 1-Deoxy-D-Xylulose-5-Phosphate ReductoisomeraseChemBioChem, 2005, 6, 1866-1874.
  • R. J. Cox,* D. J. Ritson, T. A. Dane, J. Berge, J. P. H. Charmant and A. Kantacha (2005) Room Temperature Palladium Catalysed Coupling of Acyl Chlorides with Terminal AlkynesChem. Commun., 2005, 1037-1039.
  • R. J. Cox,* J. S. Gibson and A. T. Hadfield (2005) Design, Synthesis and Analysis of Inhibitors of Bacterial Aspartate Semi-aldehyde DehydrogenaseChemBioChem, 2005, 6, 2255-2260
    DOI: 10.1002/cbic.200500172
  • S. M. Cooper, R. J. Cox, J. Crosby, M. P. Crump, J. Hothersall, W. Laosripaiboon, T. J. Simpson* and C. M. Thomas (2005) Mupirocin W, a Novel Pseudomonic Acid Produced by Targeted Mutation of the Mupirocin Biosynthetic Gene ClusterChem. Commun., 2005, 1179-1181.
  • S.M. Cooper, W. Laosripaiboon, J. Hothersall, A. K. El-Sayed, C. Winfield, J. Crosby, R. J. Cox, T. J. Simpson and C. M. Thomas,* (2005) Shift to Pseudomonic Acid B Production in Pseudomonas fluorescens NCIMB 10856 by Mutation of Mupirocin Tailoring Genes mupO, mupU and mupVChem. Biol., 2005, 12, 825-833.
  • L. A. Adams, J. P. H. Charmant, R. J. Cox,* M. Walter and W. G. Whittingham (2004) Efficient Synthesis of Protected Cyclopropyl β-AspartylphosphatesOrg. Biomol. Chem., 2004, 2, 542-553.
  • R. J. Cox* and F. Glod (2004) Fungal Secondary Metabolism in the Information Age, in Advances in Fungal Biotechnology for Industry, Agriculture, and MedicineKluwer Press, 2004, New York, pp 69-81.
  • R. J. Cox,* F. Glod, D. Hurley, C. M. Lazarus, T. P. Nicholson, B. A. M. Rudd, T. J. Simpson, B. Wilkinson and Y. Zhang (2004) Rapid Cloning and Expression of a Fungal Polyketide Synthase Gene Involved in Squalestatin BiosynthesisChem. Commun., 2004, 20, 2260-2261.
  • R. J. Cox,* F. Glod, T. J. Simpson, C. M. Lazarus and Z. Song (2004) Biosynthesis of Fusarin C in Fusarium moniliforme and Fusarium venenatumChemBioChem, 2004, 5, 1196-1203.
    DOI: 10.1002/cbic.200400138
  • R. J. Cox,* J. Berge and D. J. Ritson (2004) Indium Mediated Allylation of Glyoxylate Oxime Ethers, Esters and CyanoformatesOrg. Biomol. Chem., 2004, 2, 1921-1933.
  • W. Teartasin, C. Limpkin, F. Glod, J. Spencer, R. J. Cox, T. J. Simpson, J. Crosby, M. P. Crump, and A. T. Hadfield,* (2004) Expression, Purification and Preliminary X-ray Diffraction Analysis of a Ketoreductase from a Type II Polyketide SynthaseActa Cryst. Sect. D., 2004, 60, 1137-1138.
  • A. Abdel-Lateff, K. M. Fisch, A. D. Wright, G. M. König (2003) A new antioxidant isobenzofuranone derivative from the algicolous marine fungus Epicoccum sp.Planta Med., 2003, 69, 831-834.
  • A. L. Dummermuth, U. Karsten, K. M. Fisch, G. M. König, C. Wiencke (2003) Responses of marine macroalgae to hydrogen-peroxide-stressJ. Exp. Mar. Biol. Ecol., 2003, 289, 103-121.
  • K. M. Fisch, V. Böhm, A. D. Wright, G. M. König (2003) Antioxidative meroterpenoids from the brown alga Cystoseira crinitaJ. Nat. Prod., 2003, 66, 968-975.
  • L. A. Adams, V. K. Aggarwal,* R. V. Bonnert, B. Bressel, R. J. Cox,* J. Shepherd, J. de Vicente, M. Walter and W. Whittingham (2003) Diastereoselective Synthesis of Cyclopropane Amino Acids Using Diazo Compounds Generated In SituJ. Org. Chem., 2003, 68, 9433-9440.
  • M. A. C. Reed, M. Schweizer, A. E. Szafranska, C. Arthur, T. P. Nicholson, R. J. Cox, J. Crosby,* M. P. Crump and T. J. Simpson (2003) The isolated Acyl Carrier Protein Domain from the Type I Rat Fatty Acid Synthase Shows Considerable Homology and Analogous Biochemical Properties to Type II Acyl Carrier ProteinsOrganic and Biomolecular Chemistry, 2003, 1, 463-471.
  • R. J. Cox,* A. de Andres-Gomez and C. R. A. Godfrey (2003) Rapid and flexible synthesis of 1-deoxy-D-xylulose-5-phosphate, the substrate for 1-deoxy-D-xylulose-5-phosphate reductoisomeraseOrg. Biomol. Chem., 2003, 1, 3173-3177.
  • T. P. Nicholson, C. Winfield, J. Westcott, J. Crosby, T. J. Simpson, and R. J. Cox,* (2003) First in vitro directed biosynthesis of new compounds by a minimal Type II polyketide synthase: evidence for the mechanism of chain length determinationJ. Chem. Soc., Chem. Commun., 2003, 686-687.
  • A. Abdel-Lateff, G. M. König, K. M. Fisch, U. Höller, P. G. Jones, A. D. Wright (2002) New antioxidant hydroquinone derivatives from the algicolous marine fungus Acremonium sp.J. Nat. Prod., 2002, 65, 1605-1611.
  • C. Arthur, R. J. Cox,* J. Crosby, M. M. Rahman, T. J. Simpson, F. Soulas, R. Spogli, A. E. Szafranska, J. Westcott and C. J. Winfield (2002) Synthesis and Characterisation of Acyl Carrier Protein Bound Polyketide AnaloguesChemBioChem, 2002, 3, 253-257.
  • L. A. Adams, R. J. Cox,* J. S. Gibson, M. B. Mayo-Martín, M. Walter and W. Whittingham (2002) A New Synthesis of Phosphoramidates: Inhibitors of Aspartate Semi-Aldehyde DehydrogenaseJ. Chem. Soc., Chem. Commun., 2002, 2004-2005.
  • R. J. Cox* (2002) Formation of N-Acyl Phosphoramidates; PhosphoramidateSynthetic Page 201, 2002, Weitere Informationen
    DOI: 10.1039/SP201
  • R. J. Cox* (2002) Epoxidation of an α-keto ester; EpoxideSynthetic Page 194, 2002, Weitere Informationen
    DOI: 10.1039/SP194
  • R. J. Cox* (2002) Reductive Hydrazination of α-ketoacid; Hydrazine carboxylic acidSynthetic Page 192, 2002, Weitere Informationen
    DOI: 10.1039/SP192
  • R. J. Cox,* (2002) BiosynthesisAnnu. Rep. Prog. Chem., Sect. B: Org. Chem., 2002, 98, 223-251.
  • R. J. Cox,* J. Crosby, O. Daltrop, F. Glod, M. Jarzabek, T. P. Nicholson, T. J. Simpson, F. Soulas and J. Westcott (2002) Cloning, expression and substrate activity of -Acyl Carrier Protein synthaseJ. Chem. Soc., Perkin Trans 1, 2002, 1644-1649.
  • R. J. Cox,* J. Durston, and D. I. Roper (2002) Synthesis and in vitro Enzyme Activity of an Oxa Analogue of Azi-DAPJ. Chem. Soc. Perkin Trans 1., 2002, 1029-1035.
  • R. J. Cox,* J. S. Gibson and B. Mayo-Martin (2002) Synthesis and in vitro activity of the first synthetic inhibitors of Aspartate semi-aldehyde dehydrogenaseChemBioChem, 2002, 3, 864-876.
  • T. S. Hitchman, A. E. Szafranska, R. J. Cox,* J. Crosby* and T. J. Simpson,* (2002) Kinetic and Mechanistic Analysis of the Malonyl-CoA:ACP Transacylase from Streptomyces coelicolor Indicates a Single Catalytically Competent Serine Nucleophile at the Active SiteBiochemistry, 2002, 41(5), 1421-1427.
  • R. J. Cox* and P. S. H. Wang (2001) Is N-acetylornithine aminotransferase the real N-succinyl-LL-diaminopimelate aminotransferase in Escherichia coli and Mycobacterium smegmatis?J. Chem. Soc., Perkin Trans. 1, 2001, 2006-2008.
  • R. J. Cox* and P. S. H. Wang (2001) Synthesis and in vitro enzyme activity of aza, oxa and thia derivatives of bacterial cell wall biosynthesis intermediatesJ. Chem. Soc., Perkin Trans. 1, 2001, 2022-2034.
  • R. J. Cox,* A. Hadfield and M. B. Mayo-Martin (2001) Difluoromethylene analogues of aspartyl phosphate: the first synthetic inhibitors of aspartate semi-aldehyde dehydrogenaseJ. Chem. Soc., Chem. Commun., 2001, 1710-1711.
  • T. P. Nicholson, B. A. M. Rudd, M. Dawson, C. M. Lazarus, T. J. Simpson and R. J. Cox,* (2001) Design and utility of oligonucleotide gene probes for fungal polyketide synthasesChem. Biol., 2001, 8, 157-178.
  • R. B. Pegg, K. M. Fisch, F. Shahidi (2000) The replacement of conventional meat curing with nitrite-free curing systemsFleischwirtschaft, 2000, 80, 86-89. (in German)
  • R. J. Cox,* (2000) BiosynthesisAnnu. Rep. Prog. Chem., Sect. B: Org. Chem., 2000, 96, 231-258.
  • R. J. Cox,* A. Sutherland, J. C. Vederas,* (2000) Bacterial Diaminopimelate Metabolism as a Target for Antibiotic DesignBioorg. Med. Chem., 2000, 8, 843-871.
  • R. J. Cox,* H. Jenkins, J. A. Schouten, R. A. Stentiford and K. J. Wareing (2000) Synthesis and in vitro enzyme activity of peptide derivatives of bacterial cell wall biosynthesis inhibitorsJ. Chem. Soc. Perkin Trans. 1, 2000, 2023-2036.
  • C. Bisang, P. F. Long J. Cortes, J. Westcott, J. Crosby, A-L Matharu, R. J. Cox, T. J. Simpson, J. Staunton and P. F. Leadlay,* (1999) A chain initiation factor common to both modular and aromatic polyketide synthasesNature, 1999, 401, 502-505.
  • A-L. Matharu, R. J. Cox, J. Crosby, K. J. Byrom and T. J. Simpson,* (1998) MCAT is not required for in vitro polyketide synthesis in a minimal actinorhodin polyketide synthase from Streptomyces coelicolorChem. Biol., 1998, 5, 699-711.
  • J. Crosby, K. J. Byrom, T. S. Hitchman, R. J. Cox, M. P. Crump, I. S. C. Findlow, M. Bibb and T. J. Simpson,* (1998) Acylation of Streptomyces Type II polyketide synthase acyl carrier proteinsFEBS Lett., 1998, 433, 132-138.
  • M. C. Moore, R. J. Cox, G. R. Duffin, and D. O'Hagan,* (1998) Synthesis and evaluation of a putative acyl tetramic acid intermediate in tenellin biosynthesis in Beauveria bassiana. A new role for tyrosineTetrahedron, 1998, 54, 9195-9206.
  • R. J. Cox,* (1998) BiosynthesisAnnu. Rep. Prog. Chem., Sect. B: Org. Chem., 1998, 94, 187-206.
  • R. J. Cox,* J. A. Schouten, R. A. Stentiford and K. J. Wareing (1998) Peptide inhibitors of N-Succinyl Diaminopimelic Acid Aminotransferase (DAP-AT): A novel class of antimicrobial compoundsBioorg. Med. Chem. Lett., 1998, 8, 945-950.
  • T. S. Hitchman, J. Crosby, K. J. Byrom, R. J. Cox and T. J. Simpson,* (1998) Catalytic self-acylation of Type II polyketide synthase acyl carrier proteinsChem. Biol., 1998, 5, 35-47.
  • R. J. Cox,* T. S. Hitchman, K. J. Byrom, I. S. C. Findlow, J. A. Tanner, J. Crosby and T. J. Simpson (1997) Post-translational modification of heterologously expressed Streptomyces Type II polyketide synthase acyl carrier proteinsFEBS Lett., 1997, 405, 267-272.
  • R. J. Cox, W. A. Sherwin, L. K. P. Lam and J. C. Vederas,* (1996) Synthesis and evaluation of novel substrates and inhibitors of N-Succinyl-LL-diaminopimelate aminotransferase (DAP-AT) from Escherichia coliJ. Am. Chem. Soc., 1996, 118, 7449-7460.
  • R. J. Cox,* (1996) The DAP Pathway to Lysine as a Target for Antimicrobial AgentsNat. Prod. Rep., 1996, 13, 29-43.
  • R. J. Cox and D. O'Hagan,* (1991) Synthesis of isotopically labelled 3-amino-2-phenylpropionic acid and its role as a precursor in the biosynthesis of tenellin and tropic acidJ. Chem. Soc., Perkin Trans. 1, 1991, 2537-2540.


  • R. J. Cox, E. Skellam, K. Williams (2018) Biosynthesis of Fungal PolyketidesThe Mycota XV:Physiology and Genetics 2018 Weitere Informationen